D-alanine—(R)-lactate ligase

D-alanine—(R)-lactate ligase (EC 6.1.2.1, VanA, VanB, VanD) is an enzyme with systematic name D-alanine:(R)-lactate ligase (ADP-forming).[1][2][3] This enzyme catalyses the following chemical reaction

D-alanine + (R)-lactate + ATP D-alanyl-(R)-lactate + ADP + phosphate
D-Alanine—(R)-lactate ligase
Identifiers
EC no.6.1.2.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The product of this enzyme can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide.

References

  1. Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT (October 1991). "Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA". Biochemistry. 30 (43): 10408–15. doi:10.1021/bi00107a007. PMID 1931965.
  2. Meziane-Cherif D, Badet-Denisot MA, Evers S, Courvalin P, Badet B (November 1994). "Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583". FEBS Letters. 354 (2): 140–2. doi:10.1016/0014-5793(94)01096-x. PMID 7957913.
  3. Perichon B, Reynolds P, Courvalin P (September 1997). "VanD-type glycopeptide-resistant Enterococcus faecium BM4339". Antimicrobial Agents and Chemotherapy. 41 (9): 2016–8. doi:10.1128/aac.41.9.2016. PMC 164056. PMID 9303405.


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