DAB2IP

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.[5][6][7]

DAB2IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAB2IP, AF9Q34, AIP-1, AIP1, DIP1/2, DAB2 interacting protein
External IDsOMIM: 609205 MGI: 1916851 HomoloGene: 13058 GeneCards: DAB2IP
Orthologs
SpeciesHumanMouse
Entrez

153090

69601

Ensembl

ENSG00000136848

ENSMUSG00000026883

UniProt

Q5VWQ8

Q3UHC7

RefSeq (mRNA)

NM_032552
NM_138709
NM_001395010

RefSeq (protein)

NP_115941
NP_619723

Location (UCSC)Chr 9: 121.57 – 121.79 MbChr 2: 35.56 – 35.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM][7]

Interactions

DAB2IP has been shown to interact with DAB2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000136848 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026883 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen H, Pong RC, Wang Z, Hsieh JT (April 2002). "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization". Genomics. 79 (4): 573–81. doi:10.1006/geno.2002.6739. PMID 11944990.
  6. Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J Biol Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
  7. "Entrez Gene: DAB2IP DAB2 interacting protein".
  8. Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone Nora; Hsieh Jer-Tsong (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. ISSN 0021-9258. PMID 11812785.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.