dATP(dGTP)—DNA purinetransferase

dATP(dGTP)—DNA purinetransferase (EC 2.6.99.1) is an enzyme with systematic name dATP(dGTP):depurinated-DNA purine transferase.[1][2] This enzyme catalyses the following chemical reaction

(1) dATP + depurinated DNA deoxyribose triphosphate + DNA
(2) dGTP + depurinated DNA deoxyribose triphosphate + DNA
dATP(dGTP)—DNA purinetransferase
Identifiers
EC no.2.6.99.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

The purine residue is transferred on to the apurinic site forming a normal glycosylic bond.

References

  1. Deutsch WA, Linn S (January 1979). "DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites". Proceedings of the National Academy of Sciences of the United States of America. 76 (1): 141–4. Bibcode:1979PNAS...76..141D. doi:10.1073/pnas.76.1.141. PMC 382892. PMID 218192.
  2. Livneh Z, Elad D, Sperling J (March 1979). "Enzymatic insertion of purine bases into depurinated DNA in vitro". Proceedings of the National Academy of Sciences of the United States of America. 76 (3): 1089–93. Bibcode:1979PNAS...76.1089L. doi:10.1073/pnas.76.3.1089. PMC 383194. PMID 375225.


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