DBC1

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[5][6][7][8][9]

BRINP1
Identifiers
AliasesBRINP1, DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDsOMIM: 602865 MGI: 1928478 HomoloGene: 8754 GeneCards: BRINP1
Orthologs
SpeciesHumanMouse
Entrez

1620

56710

Ensembl

ENSG00000078725

ENSMUSG00000028351

UniProt

O60477

Q920P3

RefSeq (mRNA)

NM_014618

NM_019967

RefSeq (protein)

NP_055433

NP_064351

Location (UCSC)Chr 9: 119.15 – 119.37 MbChr 4: 68.68 – 68.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[7]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

  1. GRCh38: Ensembl release 89: ENSG00000078725 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028351 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  6. Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
  7. "Entrez Gene: DBC1 deleted in bladder cancer 1".
  8. Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  9. Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Further reading


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