DCAF15

DCAF15
Identifiers
Aliases	DCAF15, C19orf72, DDB1 and CUL4 associated factor 15
External IDs	MGI: 2684420 HomoloGene: 18182 GeneCards: DCAF15
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	13,961,449 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	84,831,397 bp[2]
RNA expression pattern
	Top expressed in
	spleen; ; blood; ; skin of abdomen; ; right uterine tube; ; lymph node; ; vagina; ; appendix; ; pituitary gland; ; ganglionic eminence; ; anterior pituitary;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; otic placode; ; saccule; ; spermatid; ; yolk sac; ; thymus; ; intestinal villus; ; somite; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Cul4-RING E3 ubiquitin ligase complex; protein-containing complex;
Biological process	protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	90379
	212123
	ENSG00000132017; ENSG00000288453
	ENSMUSG00000037103
	Q66K64
	Q6PFH3
	NM_138353
	NM_172502; NM_001357322
	NP_612362
	NP_766090; NP_001344251
	Wikidata
View/Edit Human	View/Edit Mouse

DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene.[5]

DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the proteasome degradation of certain proteins.[6]

References

ENSG00000288453 GRCh38: Ensembl release 89: ENSG00000132017, ENSG00000288453 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037103 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: DDB1 and CUL4 associated factor 15".
Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D (April 2017). "Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15". Science. 356 (6336): eaal3755. doi:10.1126/science.aal3755. PMID 28302793. S2CID 3885214.

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