CLEC4A

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.[5][6]

CLEC4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLEC4A, CLECSF6, DCIR, DDB27, LLIR, CD367, HDCGC13P, C-type lectin domain family 4 member A, hDCIR
External IDsOMIM: 605306 MGI: 1349412 HomoloGene: 49291 GeneCards: CLEC4A
Orthologs
SpeciesHumanMouse
Entrez

50856

26888

Ensembl

ENSG00000111729

ENSMUSG00000030148

UniProt

Q9UMR7

Q9QZ15

RefSeq (mRNA)

NM_016184
NM_194447
NM_194448
NM_194450

NM_001170332
NM_001170333
NM_011999

RefSeq (protein)

NP_057268
NP_919429
NP_919430
NP_919432

NP_001163803
NP_001163804
NP_036129

Location (UCSC)Chr 12: 8.12 – 8.14 MbChr 6: 123.08 – 123.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response.

Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000111729 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030148 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol. 163 (4): 1973–83. PMID 10438934.
  6. "Entrez Gene: CLEC4A C-type lectin domain family 4, member A".

Further reading


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