DDT (gene)

DDT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q3F, 3KAN, 1DPT
Identifiers
Aliases	DDT, DDCT, D-dopachrome tautomerase, MIF-2, MIF2, D-DT
External IDs	OMIM: 602750 MGI: 1298381 HomoloGene: 1038 GeneCards: DDT
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	23,979,828 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	75,609,248 bp[2]
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; kidney; ; body of stomach; ; left ventricle; ; fundus; ; right adrenal gland; ; duodenum; ; left adrenal gland; ; substantia nigra;
	Top expressed in
	proximal tubule; ; spermatocyte; ; yolk sac; ; kidney; ; testicle; ; white adipose tissue; ; liver; ; adrenal gland; ; pancreas; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopachrome isomerase activity; D-dopachrome decarboxylase activity; lyase activity; cytokine receptor binding; phenylpyruvate tautomerase activity;
Cellular component	cytoplasm; extracellular exosome; extracellular space;
Biological process	melanin biosynthetic process; negative regulation of macrophage chemotaxis; positive regulation of tumor necrosis factor production; positive regulation of inflammatory response; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	1652
	13202
	ENSG00000099977; ENSG00000275003
	ENSMUSG00000001666
	P30046
	O35215
	NM_001084392; NM_001355; NM_001381852; NM_001397485
	NM_010027
	NP_001077861; NP_001346; NP_001368781
	NP_034157
	Wikidata
View/Edit Human	View/Edit Mouse

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.[5][6][7]

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.[7]

References

ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001666 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.
Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.
"Entrez Gene: DDT D-dopachrome tautomerase".

Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Odh G, Hindemith A, Rosengren AM, et al. (1994). "Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole". Biochem. Biophys. Res. Commun. 197 (2): 619–24. doi:10.1006/bbrc.1993.2524. PMID 8267597.
Esumi N, Budarf M, Ciccarelli L, et al. (1999). "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF". Mamm. Genome. 9 (9): 753–7. doi:10.1007/s003359900858. PMID 9716662. S2CID 24034990.
Sugimoto H, Taniguchi M, Nakagawa A, et al. (1999). "Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution". Biochemistry. 38 (11): 3268–79. doi:10.1021/bi982184o. PMID 10079069.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Lubetsky JB, Dios A, Han J, et al. (2002). "The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents". J. Biol. Chem. 277 (28): 24976–82. doi:10.1074/jbc.M203220200. PMID 11997397.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Sonesson B, Rosengren E, Hansson AS, Hansson C (2004). "UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor". Exp. Dermatol. 12 (3): 278–82. doi:10.1034/j.1600-0625.2003.120307.x. PMID 12823441. S2CID 12494872.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001666 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480844-5] Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.

[pmid9729470-6] Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.

[entrez-7] "Entrez Gene: DDT D-dopachrome tautomerase".

DDT (gene)

See also

References

Further reading