DDT (gene)

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.[5][6][7]

DDT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDDT, DDCT, D-dopachrome tautomerase, MIF-2, MIF2, D-DT
External IDsOMIM: 602750 MGI: 1298381 HomoloGene: 1038 GeneCards: DDT
Orthologs
SpeciesHumanMouse
Entrez

1652

13202

Ensembl

ENSG00000099977
ENSG00000275003

ENSMUSG00000001666

UniProt

P30046

O35215

RefSeq (mRNA)

NM_001084392
NM_001355
NM_001381852
NM_001397485

NM_010027

RefSeq (protein)

NP_001077861
NP_001346
NP_001368781

NP_034157

Location (UCSC)Chr 22: 23.97 – 23.98 MbChr 10: 75.61 – 75.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.[7]

See also

References

  1. ENSG00000275003 GRCh38: Ensembl release 89: ENSG00000099977, ENSG00000275003 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001666 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.
  6. Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3) (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.
  7. "Entrez Gene: DDT D-dopachrome tautomerase".

Further reading


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