DDX1

ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene.[5][6]

DDX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDDX1, DBP-RB, UKVH5d, DEAD/H-box helicase 1, DEAD-box helicase 1
External IDsOMIM: 601257 MGI: 2144727 HomoloGene: 3627 GeneCards: DDX1
Orthologs
SpeciesHumanMouse
Entrez

1653

104721

Ensembl

ENSG00000079785

ENSMUSG00000037149

UniProt

Q92499

Q91VR5

RefSeq (mRNA)

NM_004939

NM_134040

RefSeq (protein)

NP_004930

NP_598801

Location (UCSC)Chr 2: 15.59 – 15.63 MbChr 12: 13.27 – 13.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.[6]

Interactions

DDX1 has been shown to interact with HNRPK.[7] DDX1 has also been tentatively shown to interact with hCLE/C14orf166/RTRAF and HSPC117 in a cap-binding complex that activates mRNA translation. [8]

References

  1. GRCh38: Ensembl release 89: ENSG00000079785 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037149 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schmid SR, Linder P (February 1992). "D-E-A-D protein family of putative RNA helicases". Molecular Microbiology. 6 (3): 283–91. doi:10.1111/j.1365-2958.1992.tb01470.x. PMID 1552844. S2CID 45727289.
  6. "Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1".
  7. Chen HC, Lin WC, Tsay YG, Lee SC, Chang CJ (October 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K" (PDF). The Journal of Biological Chemistry. 277 (43): 40403–9. doi:10.1074/jbc.M206981200. PMID 12183465. S2CID 25252628.
  8. Cho WJ, Yoon WJ, Moon CH, Cha SJ, Song H, Cho HR, Jang SJ, Chung DK, Jeong CS, Park JW (November 2002). "Molecular cloning of a novel chaperone-like protein induced by rhabdovirus infection with sequence similarity to the bacterial extracellular solute-binding protein family 5". The Journal of Biological Chemistry. 277 (44): 41489–96. doi:10.1074/jbc.M207104200. PMID 12183466.

Further reading


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