DGKD

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.[5][6][7]

DGKD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDGKD, DGKdelta, dgkd-2, diacylglycerol kinase delta, DGK-delta
External IDsOMIM: 601826 MGI: 2138334 HomoloGene: 100054 GeneCards: DGKD
Orthologs
SpeciesHumanMouse
Entrez

8527

227333

Ensembl

ENSG00000077044
ENSG00000280873

ENSMUSG00000070738

UniProt

Q16760

E9PUQ8

RefSeq (mRNA)

NM_003648
NM_152879
NM_001377259

NM_177646

RefSeq (protein)

NP_003639
NP_690618
NP_001364188

NP_808314

Location (UCSC)Chr 2: 233.35 – 233.47 MbChr 1: 87.78 – 87.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.[7]

References

  1. ENSG00000280873 GRCh38: Ensembl release 89: ENSG00000077044, ENSG00000280873 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000070738 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.
  6. Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem. 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723.
  7. "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa".

Further reading


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