DHPS

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.[5][6]

DHPS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDHPS, deoxyhypusine synthase, DHS, DS, MIG13, NEDSSWI
External IDsOMIM: 600944 MGI: 2683592 HomoloGene: 1453 GeneCards: DHPS
EC number2.5.1.46
Orthologs
SpeciesHumanMouse
Entrez

1725

330817

Ensembl

ENSG00000095059

ENSMUSG00000060038

UniProt

P49366

Q3TXU5

RefSeq (mRNA)

NM_001039514
NM_201408

RefSeq (protein)

NP_001034603

Location (UCSC)Chr 19: 12.68 – 12.68 MbChr 8: 85.8 – 85.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A (EIF5A, EIF5A2). In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000095059 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000060038 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Joe YA, Wolff EC, Park MH (Oct 1995). "Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins". J Biol Chem. 270 (38): 22386–92. doi:10.1074/jbc.270.38.22386. PMID 7673224.
  6. "Entrez Gene: DHPS deoxyhypusine synthase".

Further reading


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