DHRS1

Dehydrogenase/reductase SDR family member 1, also known as Short chain dehydrogenase/reductase family 19C member 1 is an enzyme that in humans is encoded by the DHRS1 gene located on chromosome 14.[5][6][7]

DHRS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDHRS1, SDR19C1, dehydrogenase/reductase (SDR family) member 1, dehydrogenase/reductase 1
External IDsOMIM: 610410 MGI: 1196314 HomoloGene: 41696 GeneCards: DHRS1
Orthologs
SpeciesHumanMouse
Entrez

115817

52585

Ensembl

ENSG00000157379
ENSG00000284868

ENSMUSG00000002332

UniProt

Q96LJ7

Q99L04

RefSeq (mRNA)

NM_001136050
NM_138452

NM_026819

RefSeq (protein)

NP_001129522
NP_612461

NP_081095

Location (UCSC)Chr 14: 24.29 – 24.3 MbChr 14: 55.98 – 55.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Structure

The DHRS1 gene is located on the chromosome 14q21.3 region and contains 9 exons. It encodes a 314-amino-acid, 33-kDa protein that is thought to be located to the endoplasmic reticulum and the mitochondrial inner membrane inside the cell.

Function

The DHRS1 protein is thought to have oxidoreductase activity based on sequence similarity and conserved catalytic sites with other short-chain oxidoreductase enzymes. The enzyme is found to be expressed in the fetal brain.[8]

Interactions

The DHRS1 protein is thought to interact with the protein phospholipid scrambase 1 (PLSCR1).[9]

References

  1. ENSG00000284868 GRCh38: Ensembl release 89: ENSG00000157379, ENSG00000284868 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002332 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, Zeng L, Xu J, Fu X, Ying K, Xie Y, Mao Y (Aug 2002). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol Biol Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID 12153138. S2CID 29552121.
  6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. "Entrez Gene: DHRS1 dehydrogenase/reductase (SDR family) member 1".
  8. Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, Zeng L, Xu J, Fu X, Ying K, Xie Y, Mao Y (2001). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol. Biol. Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID 12153138. S2CID 29552121.
  9. "IntAct Portal".

Further reading


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