DHX16

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is an enzyme that in humans is encoded by the DHX16 gene.[5][6]

DHX16
Identifiers
AliasesDHX16, DBP2, DDX16, PRO2014, PRP8, PRPF2, Prp2, DEAH-box helicase 16, NMOAS
External IDsOMIM: 603405 MGI: 1916442 HomoloGene: 2658 GeneCards: DHX16
Orthologs
SpeciesHumanMouse
Entrez

8449

69192

Ensembl

ENSMUSG00000024422

UniProt

O60231
Q5SQH5

n/a

RefSeq (mRNA)

NM_001164239
NM_003587
NM_001363515

NM_026987

RefSeq (protein)

NP_001157711
NP_003578
NP_001350444

n/a

Location (UCSC)Chr 6: 30.65 – 30.67 MbChr 17: 36.19 – 36.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked.[6]

References

Further reading


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