DIS3

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene.[5][6] Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.[7][8]

DIS3
Identifiers
AliasesDIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
External IDsOMIM: 607533 MGI: 1919912 HomoloGene: 6910 GeneCards: DIS3
Orthologs
SpeciesHumanMouse
Entrez

22894

72662

Ensembl

ENSG00000083520

ENSMUSG00000033166

UniProt

Q9Y2L1

Q9CSH3

RefSeq (mRNA)

NM_001128226
NM_014953
NM_001322348
NM_001322349

NM_028315
NM_001360050
NM_001360051

RefSeq (protein)

NP_001121698
NP_001309277
NP_001309278
NP_055768

NP_082591
NP_001346979
NP_001346980

Location (UCSC)Chr 13: 72.75 – 72.78 MbChr 14: 99.31 – 99.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000083520 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033166 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, Haraldsson K, Johannsdottir HK, Vehmanen P, Nigam S, Golberger N, Robbins C, Pak E, Dutra A, Gillander E, Stephan DA, Bailey-Wilson J, Juo SH, Kainu T, Arason A, Barkardottir RB, Nevanlinna H, Borg A, Kallioniemi OP (Apr 2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Hum Genet. 110 (2): 111–21. doi:10.1007/s00439-001-0646-6. PMID 11935316. S2CID 21371347.
  6. Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E, Nishimoto T (Jul 1998). "Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3". J Biochem. 123 (5): 883–90. doi:10.1093/oxfordjournals.jbchem.a022020. PMID 9562621.
  7. "Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)".
  8. Tomecki, R.; Kristiansen, MS; Lykke-Andersen, S; Chlebowski, A; Larsen, KM; Szczesny, RJ; Drazkowska, K; Pastula, A; et al. (2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". The EMBO Journal. 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.

Further reading


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