DKK3

Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene.[5][6]

DKK3
Identifiers
AliasesDKK3, REIC, RIG, dickkopf WNT signaling pathway inhibitor 3, CRRL
External IDsOMIM: 605416 MGI: 1354952 HomoloGene: 8303 GeneCards: DKK3
Orthologs
SpeciesHumanMouse
Entrez

27122

50781

Ensembl

ENSG00000050165

ENSMUSG00000030772

UniProt

Q9UBP4

Q9QUN9

RefSeq (mRNA)

NM_001018057
NM_013253
NM_015881
NM_001330220

NM_015814
NM_001360257
NM_001360260
NM_001360261

RefSeq (protein)

NP_001018067
NP_001317149
NP_037385
NP_056965

NP_056629
NP_001347186
NP_001347189
NP_001347190

Location (UCSC)Chr 11: 11.96 – 12.01 MbChr 7: 111.72 – 111.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000050165 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030772 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
  6. "Entrez Gene: DKK3 dickkopf homolog 3 (Xenopus laevis)".

Further reading


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