DLG5

Disks large homolog 5 is a protein that in humans is encoded by the DLG5 gene.[5][6]

DLG5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDLG5, LP-DLG, P-PDLG, discs large homolog 5, discs large MAGUK scaffold protein 5
External IDsOMIM: 604090 MGI: 1918478 HomoloGene: 3486 GeneCards: DLG5
Orthologs
SpeciesHumanMouse
Entrez

9231

71228

Ensembl

ENSG00000151208
ENSG00000274429

ENSMUSG00000021782

UniProt

Q8TDM6

E9Q9R9

RefSeq (mRNA)

NM_004747

NM_001163513
NM_027726

RefSeq (protein)

NP_004738

NP_001156985
NP_082002

Location (UCSC)Chr 10: 77.79 – 77.93 MbChr 14: 24.18 – 24.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.[6]

Interactions

DLG5 has been shown to interact with SORBS3.[7]

References

  1. ENSG00000274429 GRCh38: Ensembl release 89: ENSG00000151208, ENSG00000274429 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021782 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nakamura H, Sudo T, Tsuiki H, Miyake H, Morisaki T, Sasaki J, Masuko N, Kochi M, Ushio Y, Saya H (Sep 1998). "Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55". FEBS Lett. 433 (1–2): 63–7. doi:10.1016/S0014-5793(98)00882-5. PMID 9738934. S2CID 29876587.
  6. "Entrez Gene: DLG5 discs, large homolog 5 (Drosophila)".
  7. Wakabayashi M, Ito T, Mitsushima M, Aizawa S, Ueda K, Amachi T, Kioka N (2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. PMID 12657639.

Further reading


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