DPP6

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.[5][6]

DPP6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPP6, DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6
External IDsOMIM: 126141 MGI: 94921 HomoloGene: 22560 GeneCards: DPP6
Orthologs
SpeciesHumanMouse
Entrez

1804

13483

Ensembl

ENSG00000130226
ENSG00000282974

ENSMUSG00000061576

UniProt

P42658
Q8IYG9

Q9Z218

RefSeq (mRNA)

NM_001039350
NM_001290252
NM_001290253
NM_001936
NM_130797

NM_001136060
NM_001198886
NM_010075
NM_207282

RefSeq (protein)

NP_001129532
NP_001185815
NP_034205
NP_997165

Location (UCSC)Chr 7: 153.89 – 154.89 MbChr 5: 27.02 – 27.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

  1. ENSG00000282974 GRCh38: Ensembl release 89: ENSG00000130226, ENSG00000282974 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061576 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S (Feb 1992). "Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family". Proc Natl Acad Sci U S A. 89 (1): 197–201. doi:10.1073/pnas.89.1.197. PMC 48203. PMID 1729689.
  6. "Entrez Gene: DPP6 dipeptidyl-peptidase 6".

Further reading


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