DPP7

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.[5][6][7]

DPP7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPP7, DPP2, DPPII, QPP, dipeptidyl peptidase 7
External IDsOMIM: 610537 MGI: 1933213 HomoloGene: 22748 GeneCards: DPP7
Orthologs
SpeciesHumanMouse
Entrez

29952

83768

Ensembl

ENSG00000176978

ENSMUSG00000026958

UniProt

Q9UHL4

Q9ET22

RefSeq (mRNA)

NM_013379

NM_031843

RefSeq (protein)

NP_037511

NP_114031

Location (UCSC)Chr 9: 137.11 – 137.12 MbChr 2: 25.24 – 25.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000176978 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026958 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol. 163 (6): 3092–9. PMID 10477574.
  6. Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J. 353 (Pt 2): 283–90. doi:10.1042/0264-6021:3530283. PMC 1221570. PMID 11139392.
  7. "Entrez Gene: DPP7 dipeptidyl-peptidase 7".

Further reading


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