DPYSL2

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.[5][6]

DPYSL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase like 2
External IDsOMIM: 602463 MGI: 1349763 HomoloGene: 74392 GeneCards: DPYSL2
Orthologs
SpeciesHumanMouse
Entrez

1808

12934

Ensembl

ENSG00000092964

ENSMUSG00000022048

UniProt

Q16555

O08553

RefSeq (mRNA)

NM_001386
NM_001197293
NM_001244604

NM_009955
NM_001378767

RefSeq (protein)

NP_001184222
NP_001231533
NP_001377

NP_034085
NP_001365696

Location (UCSC)Chr 8: 26.51 – 26.66 MbChr 14: 67.04 – 67.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

DPYSL2 has been shown to interact with CRMP1,[7] Adaptor-related protein complex 2, alpha 1[8] and NUMB.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000092964 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022048 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
  6. "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
  7. Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. Netherlands. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610. S2CID 45499981.
  8. Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. England. 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088. S2CID 12118386.

Further reading


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