DPYSL3

DPYSL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BKN, 4CNS, 4CNT, 4CNU
Identifiers
Aliases	DPYSL3, CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1, dihydropyrimidinase like 3
External IDs	OMIM: 601168 MGI: 1349762 HomoloGene: 20361 GeneCards: DPYSL3
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	147,510,068 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	43,571,351 bp[2]
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; saphenous vein; ; gastric mucosa; ; right coronary artery; ; ascending aorta; ; urethra; ; optic nerve; ; smooth muscle tissue; ; spinal ganglia; ; myometrium;
	Top expressed in
	superior cervical ganglion; ; barrel cortex; ; ganglionic eminence; ; seminiferous tubule; ; optic nerve; ; medial ganglionic eminence; ; neural tube; ; sexually immature organism; ; pineal gland; ; atrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; chondroitin sulfate binding; hydrolase activity; filamin binding;
Cellular component	cytoplasm; cell body; filamentous actin; cytosol; cell projection; exocytic vesicle; growth cone; lamellipodium; extracellular space; synapse;
Biological process	negative regulation of neuron projection development; regulation of cell migration; regulation of neuron projection development; neuron development; actin filament bundle assembly; negative regulation of cell migration; response to axon injury; actin crosslink formation; positive regulation of neuron projection development; protein homooligomerization; positive regulation of filopodium assembly; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	1809
	22240
	ENSG00000113657
	ENSMUSG00000024501
	Q14195
	Q62188
	NM_001197294; NM_001387
	NM_001136086; NM_001291455; NM_009468
	NP_001184223; NP_001378
	NP_001129558; NP_001278384; NP_033494
	Wikidata
View/Edit Human	View/Edit Mouse

Dihydropyrimidinase-related protein 3 is an enzyme that in humans is encoded by the DPYSL3 gene.[5][6][7] A recent bioinformatics study suggested that the DPYSL3 gene might have a prognostic role in neuroblastoma.[8]

References

GRCh38: Ensembl release 89: ENSG00000113657 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024501 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (November 1996). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–163. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
Gaetano C, Matsuo T, Thiele CJ (May 1997). "Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells". The Journal of Biological Chemistry. 272 (18): 12195–12201. doi:10.1074/jbc.272.18.12195. PMID 9115293.
"Entrez Gene: DPYSL3 dihydropyrimidinase-like 3".
Chicco D, Sanavia T, Jurman G (March 2023). "Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma". BioData Mining. 16 (1): 7. doi:10.1186/s13040-023-00325-1. eISSN 1756-0381. PMC 9985261. PMID 36870971.

Dawson SJ, White LA (May 1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". The Journal of Infection. 24 (3): 317–320. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Inagaki H, Kato Y, Hamajima N, Nonaka M, Sasaki M, Eimoto T (January 2000). "Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system". Histochemistry and Cell Biology. 113 (1): 37–41. doi:10.1007/s004180050005. PMID 10664068. S2CID 11121195.
Matsuo T, Stauffer JK, Walker RL, Meltzer P, Thiele CJ (June 2000). "Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts". The Journal of Biological Chemistry. 275 (22): 16560–16568. doi:10.1074/jbc.M001312200. PMID 10748015.
Fukada M, Watakabe I, Yuasa-Kawada J, Kawachi H, Kuroiwa A, Matsuda Y, Noda M (December 2000). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". The Journal of Biological Chemistry. 275 (48): 37957–37965. doi:10.1074/jbc.M003277200. PMID 10956643.
Weitzdoerfer R, Fountoulakis M, Lubec G (2001). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain". Protein Expression in Down Syndrome Brain. pp. 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN 978-3-211-83704-7. PMID 11771764. {{cite book}}: |journal= ignored (help)
Franken S, Junghans U, Rosslenbroich V, Baader SL, Hoffmann R, Gieselmann V, et al. (January 2003). "Collapsin response mediator proteins of neonatal rat brain interact with chondroitin sulfate". The Journal of Biological Chemistry. 278 (5): 3241–3250. doi:10.1074/jbc.M210181200. PMID 12444086.
Rosslenbroich V, Dai L, Franken S, Gehrke M, Junghans U, Gieselmann V, Kappler J (May 2003). "Subcellular localization of collapsin response mediator proteins to lipid rafts". Biochemical and Biophysical Research Communications. 305 (2): 392–399. doi:10.1016/S0006-291X(03)00754-X. PMID 12745088.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–1101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Choi YL, Kim CJ, Matsuo T, Gaetano C, Falconi R, Suh YL, et al. (May 2005). "HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors". Journal of Neuro-Oncology. 73 (1): 19–27. doi:10.1007/s11060-004-3013-3. PMID 15933812. S2CID 25655752.
Cole AR, Causeret F, Yadirgi G, Hastie CJ, McLauchlan H, McManus EJ, et al. (June 2006). "Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo". The Journal of Biological Chemistry. 281 (24): 16591–16598. doi:10.1074/jbc.M513344200. PMC 1805471. PMID 16611631.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Chicco D, Sanavia T, Jurman G (March 2023). "Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma". BioData Mining. 16 (1): 7. doi:10.1186/s13040-023-00325-1. eISSN 1756-0381. PMC 9985261. PMID 36870971.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113657 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024501 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973361-5] Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (November 1996). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–163. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.

[pmid9115293-6] Gaetano C, Matsuo T, Thiele CJ (May 1997). "Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells". The Journal of Biological Chemistry. 272 (18): 12195–12201. doi:10.1074/jbc.272.18.12195. PMID 9115293.

[entrez-7] "Entrez Gene: DPYSL3 dihydropyrimidinase-like 3".

[ChiccoSanaviaJurman2023-8] Chicco D, Sanavia T, Jurman G (March 2023). "Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma". BioData Mining. 16 (1): 7. doi:10.1186/s13040-023-00325-1. eISSN 1756-0381. PMC 9985261. PMID 36870971.

DPYSL3

References

Further reading