DRG2

Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene.[5][6][7]

DRG2
Identifiers
AliasesDRG2, developmentally regulated GTP binding protein 2
External IDsOMIM: 602986 MGI: 1342307 HomoloGene: 1061 GeneCards: DRG2
Orthologs
SpeciesHumanMouse
Entrez

1819

13495

Ensembl

ENSG00000108591

ENSMUSG00000020537

UniProt

P55039

Q9QXB9

RefSeq (mRNA)

NM_001388
NM_001330144

NM_021354

RefSeq (protein)

NP_001317073
NP_001379

NP_067329

Location (UCSC)Chr 17: 18.09 – 18.11 MbChr 11: 60.35 – 60.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000108591 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020537 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schenker T, Trueb B (Jun 1998). "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 274–5. doi:10.1159/000134741. PMID 9605870.
  6. Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi:10.1016/S0021-9258(18)47271-7. PMID 7929244.
  7. "Entrez Gene: DRG2 developmentally regulated GTP binding protein 2".

Further reading


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