DTL (gene)

DTL
Identifiers
Aliases	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDs	OMIM: 610617 MGI: 1924093 HomoloGene: 32313 GeneCards: DTL
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	212,107,400 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	191,307,656 bp[2]
RNA expression pattern
	Top expressed in
	secondary oocyte; ; cancellous bone; ; embryo; ; bone marrow; ; ganglionic eminence; ; bone marrow cells; ; sperm; ; testicle; ; hair follicle; ; thymus;
	Top expressed in
	maxillary prominence; ; secondary oocyte; ; ureter; ; primitive streak; ; hand; ; cumulus cell; ; vas deferens; ; abdominal wall; ; somite; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding;
Cellular component	centrosome; nuclear membrane; membrane; chromosome; microtubule organizing center; nucleolus; Cul4A-RING E3 ubiquitin ligase complex; Cul4B-RING E3 ubiquitin ligase complex; cytoskeleton; nucleus; nucleoplasm; cytoplasm; cytosol; Cul4-RING E3 ubiquitin ligase complex;
Biological process	ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein monoubiquitination; regulation of cell cycle; DNA replication; protein ubiquitination; response to UV; translesion synthesis; post-translational protein modification; cellular response to DNA damage stimulus; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of protein catabolic process; mitotic G2 DNA damage checkpoint signaling; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	51514
	76843
	ENSG00000143476
	ENSMUSG00000037474
	Q9NZJ0
	Q3TLR7
	NM_001286229; NM_001286230; NM_016448
	NM_029766; NM_001305233
	NP_001273158; NP_001273159; NP_057532
	NP_001292162; NP_084042
	Wikidata
View/Edit Human	View/Edit Mouse

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.[5][6]

Interactions

DTL (gene) has been shown to interact with P21.[7]

References

GRCh38: Ensembl release 89: ENSG00000143476 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037474 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.
"Entrez Gene: DTL denticleless homolog (Drosophila)".
Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes". Cell Cycle. 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.
Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage". Cell Cycle. 5 (15): 1675–80. doi:10.4161/cc.5.15.3149. PMID 16861906.
Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1". Mol. Cell. 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588. S2CID 22180568.
Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint". Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480.
Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma". Cell Cycle. 5 (22): 2676–87. doi:10.4161/cc.5.22.3500. PMID 17106265.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143476 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037474 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11278750-5] Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.

[entrez-6] "Entrez Gene: DTL denticleless homolog (Drosophila)".

[pmid18794347-7] Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

DTL (gene)

Interactions

References

Further reading