DTL (gene)

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.[5][6]

DTL
Identifiers
AliasesDTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDsOMIM: 610617 MGI: 1924093 HomoloGene: 32313 GeneCards: DTL
Orthologs
SpeciesHumanMouse
Entrez

51514

76843

Ensembl

ENSG00000143476

ENSMUSG00000037474

UniProt

Q9NZJ0

Q3TLR7

RefSeq (mRNA)

NM_001286229
NM_001286230
NM_016448

NM_029766
NM_001305233

RefSeq (protein)

NP_001273158
NP_001273159
NP_057532

NP_001292162
NP_084042

Location (UCSC)Chr 1: 212.04 – 212.11 MbChr 1: 191.27 – 191.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

DTL (gene) has been shown to interact with P21.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000143476 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037474 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.
  6. "Entrez Gene: DTL denticleless homolog (Drosophila)".
  7. Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.