Deltex e3 ubiquitin ligase 3

DTX3
Identifiers
Aliases	DTX3, RNF154, deltex3, deltex 3, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3
External IDs	OMIM: 613142 MGI: 2135752 HomoloGene: 12754 GeneCards: DTX3
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	57,609,804 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	127,195,728 bp[2]
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right uterine tube; ; endothelial cell; ; nucleus accumbens; ; caudate nucleus; ; ganglionic eminence; ; canal of the cervix; ; amygdala; ; left uterine tube; ; gastric mucosa;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; habenula; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; spermatocyte; ; subiculum; ; neural tube; ; superior colliculus; ; optic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; transferase activity; zinc ion binding;
Cellular component	cytoplasm;
Biological process	Notch signaling pathway; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	196403
	80904
	ENSG00000178498
	ENSMUSG00000040415
	Q8N9I9
	Q80V91
	NM_001286245; NM_001286246; NM_178502
	NM_030714; NM_001368332
	NP_001273174; NP_001273175; NP_848597
	NP_109639; NP_001355261
	Wikidata
View/Edit Human	View/Edit Mouse

Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene. [5]

Function

DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).

GRCh38: Ensembl release 89: ENSG00000178498 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040415 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Deltex E3 ubiquitin ligase 3". Retrieved 2016-09-26.