DUSP13

Dual specificity phosphatase 13 is an enzyme that in humans is encoded by the DUSP13 gene.[5]

DUSP13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDUSP13, BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP, dual specificity phosphatase 13
External IDsOMIM: 613191 MGI: 1351599 HomoloGene: 121602 GeneCards: DUSP13
Orthologs
SpeciesHumanMouse
Entrez

51207

27389

Ensembl

ENSG00000079393

ENSMUSG00000021768

UniProt

Q6B8I1
Q9UII6

Q6B8I0
Q9QYJ7

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 10: 75.09 – 75.11 MbChr 14: 21.78 – 21.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000079393 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021768 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: DUSP13 dual specificity phosphatase 13".

Further reading

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