dcGO

dcGO is a comprehensive ontology database for protein domains.[1] As an ontology resource, dcGO integrates Open Biomedical Ontologies from a variety of contexts, ranging from functional information like Gene Ontology to others on enzymes and pathways, from phenotype information across major model organisms to information about human diseases and drugs. As a protein domain resource, dcGO includes annotations to both the individual domains and supra-domains (i.e., combinations of two or more successive domains).

dcGO
Content
DescriptionThe dcGO database is a comprehensive domain-centric ontology resource for protein domains.
Data types
captured		Protein domains, ontologies
Contact
Research centerUniversity of Bristol
Primary citationPMID 23161684
Access
WebsiteThe dcGO website
Download URLdcGO DOWNLOAD
Tools
WebPSnet, sTOL, dcGOR, dcGO Predictor, dcGO Enrichment

Concepts

There are two key concepts behind dcGO. The first concept is to label protein domains with ontology, for example, with Gene Ontology. That is why it is called dcGO, domain-centric Gene Ontology. The second concept is to use ontology-labeled protein domains for, for example, protein function prediction. Put it in a simple way, the first concept is about how to create dcGO resource, and the second concept is about how to use dcGO resource.

Timelines
  • In 2010, the algorithm behind the dcGO was initially published as an improvement to the SUPERFAMILY database.[2]
  • In 2011, the 'dcGO Predictor' was ranked 10th in the 2011 CAFA competition when applied to Gene Ontology.[3][4] This predictor is only domain-based method without machine learning.
  • In 2012, the database was officially released, published in NAR database issue.
  • In 2013, the webserver was improved to support many analyses using dcGO resource.
  • In the early 2014, the 'dcGO Predictor' was submitted for both function and phenotype predictions, ranked top in 4th in CAFA phenotype prediction.
  • In the late 2014, an open-source R package dcGOR was developed to help analyse ontologies and protein domain annotations.

Webserver

Recent use of dcGO is to build a domain network from a functional perspective for cross-ontology comparisons,[5] and to combine with species tree of life (sTOL) to provide a phylogenetic context to function and phenotype.[6]

Software

Open-source software dcGOR is developed using R programming language to analyse domain-centric ontologies and annotations.[7] Supported analyses include:

  • easy access to a wide range of ontologies and their domain-centric annotations;
  • able to build customised ontologies and annotations;
  • domain-based enrichment analysis and visualisation;
  • construction of a domain (semantic similarity) network according to ontology annotations;
  • significance analysis for estimating a contact (statistical significance) network using random walker algorithm;
  • high-performance parallel computing.

Functionalities under active development are:

  • algorithm and implementations for creating domain-centric ontology annotations;
  • ontology term prediction for input protein domain architectures;
  • reconstruction of ancestral discrete characters using maximum likelihood/parsimony.

See also

References
  1. Fang, H.; Gough, J. (2012). "DcGO: Database of domain-centric ontologies on functions, phenotypes, diseases and more". Nucleic Acids Research. 41 (Database issue): D536–D544. doi:10.1093/nar/gks1080. PMC 3531119. PMID 23161684.
  2. De Lima Morais, D. A.; Fang, H.; Rackham, O. J. L.; Wilson, D.; Pethica, R.; Chothia, C.; Gough, J. (2010). "SUPERFAMILY 1.75 including a domain-centric gene ontology method". Nucleic Acids Research. 39 (Database issue): D427–D434. doi:10.1093/nar/gkq1130. PMC 3013712. PMID 21062816.
  3. Fang, H.; Gough, J. (2013). "A domain-centric solution to functional genomics via dcGO Predictor". BMC Bioinformatics. 14 Suppl 3: S9. doi:10.1186/1471-2105-14-S3-S9. PMC 3584936. PMID 23514627.
  4. Radivojac, P.; Clark, W. T.; Oron, T. R.; Schnoes, A. M.; Wittkop, T.; Sokolov, A.; Graim, K.; Funk, C.; Verspoor, K.; Ben-Hur, A.; Pandey, G.; Yunes, J. M.; Talwalkar, A. S.; Repo, S.; Souza, M. L.; Piovesan, D.; Casadio, R.; Wang, Z.; Cheng, J.; Fang, H.; Gough, J.; Koskinen, P.; Törönen, P.; Nokso-Koivisto, J.; Holm, L.; Cozzetto, D.; Buchan, D. W. A.; Bryson, K.; Jones, D. T.; et al. (2013). "A large-scale evaluation of computational protein function prediction". Nature Methods. 10 (3): 221–227. doi:10.1038/nmeth.2340. PMC 3584181. PMID 23353650.
  5. Fang, H; Gough, J (2013). "A disease-drug-phenotype matrix inferred by walking on a functional domain network". Molecular BioSystems. 9 (7): 1686–96. doi:10.1039/c3mb25495j. PMID 23462907.
  6. Fang, H.; Oates, M. E.; Pethica, R. B.; Greenwood, J. M.; Sardar, A. J.; Rackham, O. J. L.; Donoghue, P. C. J.; Stamatakis, A.; De Lima Morais, D. A.; Gough, J. (2013). "A daily-updated tree of (sequenced) life as a reference for genome research". Scientific Reports. 3: 2015. Bibcode:2013NatSR...3E2015F. doi:10.1038/srep02015. PMC 6504836. PMID 23778980.
  7. Fang, H (2014). "DcGOR: An R package for analysing ontologies and protein domain annotations". PLOS Computational Biology. 10 (10): e1003929. Bibcode:2014PLSCB..10E3929F. doi:10.1371/journal.pcbi.1003929. PMC 4214615. PMID 25356683.
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