Dehydrocorybulbine

Dehydrocorybulbine (DHCB) is an alkaloid isolated from Corydalis yanhusuo.[1] Dehydrocorybulbine binds to the dopamine D1 receptor.[1]

Dehydrocorybulbine
Names
IUPAC name
3-Hydroxy-2,9,10-trimethoxy-13-methyl-7,8,13,13a-tetradehydroberbin-7-ium
Systematic IUPAC name
3-Hydroxy-2,9,10-trimethoxy-13-methyl-5,6-dihydro-7λ5-isoquinolino[3,2-a]isoquinolin-7-ylium
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C21H21NO4/c1-12-14-5-6-18(24-2)21(26-4)16(14)11-22-8-7-13-9-17(23)19(25-3)10-15(13)20(12)22/h5-6,9-11H,7-8H2,1-4H3/p+1
    Key: XWCVASCMRTXXRY-UHFFFAOYSA-O
  • O(c4cc3c2c(c1ccc(OC)c(OC)c1c[n+]2CCc3cc4O)C)C
Properties
C21H22NO4+
Molar mass 352.40 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Research has indicated that DHCB can be helpful in reducing neuropathic pain.[2][3]

References
  1. Ma, ZZ; Xu, W; Jensen, NH; Roth, BL; Liu-Chen, LY; Lee, DY (2008). "Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor". Molecules (Basel, Switzerland). 13 (9): 2303–12. doi:10.3390/molecules13092303. PMC 6245449. PMID 18830156.
  2. Chinese herbal compound relieves inflammatory and neuropathic pain
  3. A Novel Analgesic Isolated from a Traditional Chinese Medicine. Current Biology. Volume 24, Issue 2, p117–123, 20 January 2014


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