Desmond's

The Ambroses are the central family around which the show was built.

• Desmond Ambrose (Norman Beaton) is the protagonist and owner of the barbershop, which is named after him. His poor barbering skills is a running joke through the series. Desmond dreams of building a house in Guyana and returning there to retire, although Shirley is reluctant to go with him. In his youth in Guyana, he played the trumpet in his band, The Georgetown Dreamers, and was known as "Jazzy D." In the spin-off Porkpie, it was revealed that Desmond had died (as Norman Beaton had died the previous year).
• Shirley Ambrose (née Pleshette) (Carmen Munroe) is Desmond's wife and mother of their three children; she works together with Desmond in the barbershop. Shirley often solves the problems of the other characters. Shirley is the only member of the Ambrose family not to appear in an episode of the spin-off Porkpie as it is revealed that she has decided to return to Guyana.
• Michael Ambrose (Geff Francis), Desmond and Shirley's elder son, is an assistant bank manager. He later becomes a manager. He was not introduced until the second episode, when Shirley suggested that Desmond go to the bank and get a loan to renovate the shop. He owns half the barbershop. Michael and Desmond have an antagonistic relationship.
• Gloria Jeanette Elaine Ambrose (Kimberly Walker) is the only daughter of Desmond and Shirley. She starts the series as a teenager finishing secondary school, and her arc follows her as she matures, aspiring to become an "independent woman of the '90s." Instead of going to university, she decides to become a fashion writer. She eventually moves out to live with her boyfriend, Alex.
• Sean Ambrose (Justin Pickett) is the youngest child in the Ambrose family. He is experienced with computers and coding. He goes through various phases over his adolescence as he discovers his identity and deals with puberty, including a period when he frequently raps and a bad boy phase. He performs ragga music with his best friend, Spider, but stops when he starts starts attending university in Series 5.

• Augustus Neapolitan Cleveland "Porkpie" Grant (Ram John Holder) is Desmond's best friend who frequently spends time at the barbershop. He plays the acoustic guitar in The Georgetown Dreamers. His nickname derives from his habit of always wearing a pork pie hat. His wife Gwendolyn left him many years earlier after catching him cheating; she took their two children with her. He becomes a lollypop man in Series 5. Porkpie has his own spin-off series, Porkpie.
• Matthew Joffor (Gyearbuor Asante) is a perpetual student from The Gambia who has spent decades studying at the university level in London, earning several degrees. He also spends a significant amount of time at the barbershop; he and Porkpie frequently bicker and insult each other. He regularly asserts the superiority of Africans over West Indians, and often interjects with, "There's an old African saying..."
• Louise Dixon (Lisa Geoghan) is Gloria's best friend in the first four series, and also the first white character to appear in the series. She goes away to university between the fourth and fifth seasons.
• Lee Stanley (Robbie Gee) is the local wide-boy wheeler-dealer, often trying to sell his wares to the regulars in the shop. He habitually flirts with women, and is a boxer under the name of The Peckham Prince. He frequently gives rides to the other characters. He does not know his mother or father until the fourth series, having grown up in a home for children, but Shirley and Desmond treat him as their son.
• Lewis (Lewis St. Juste) is very often in the background of the barbershop, using the payphone; however, he has very few lines over the course of the series. He first speaks in the third episode of the second series, when Shirley asked him his name.
• Amanda "Mandy" Mosgrove (Matilda Thorpe) is Michael's PA and is obviously infatuated with him, although Michael does not realize until the fifth series, when they start dating. She is the second white character to appear in the series. In episode two of the sixth series, Michael proposes to her. In Series 6, she becomes a becomes a financial director of an art gallery. In the spin-off series, Porkpie, it is revealed that Mandy married Michael and took the Ambrose surname.
• Tony (Dominic Keating) is hired by Michael as the part-time hairstylist for Desmond's barbershop to bring in more customers. He is the third white character to appear in the series, and of the white characters, he appears the most frequently. Tony often wears colourful, eccentric outfits and is regarded by the younger characters as "cool." He leaves between Seasons 5 and 6 to become a hairdresser on a cruise ship.
• Doreen Wilma "Susu" Pleshette (Mona Hammond), usually referred to as Auntie Susu, is Shirley's sister who acts and dresses much younger than her age. She has a number of romantic and sexual dalliances. Prior to her engagement to Porkpie, she was married to (and divorced from) Maxwell, with whom she had several sons. In the fourth series, Susu gets deported to Jamaica; in the final series of the spin-off show Porkpie, she returns to England to marry Porkpie.
• Neville "Nev" James (Treva Etienne) is a friend of the Ambrose family who was a police constable; he later becomes a Detective Constable CID. He went to school with Lee and Michael as a child. He only appears in three episodes across the second and third seasons.
• Beverley McIntosh (Joan Ann Maynard) is a good friend of Shirley's, Michael's godmother and the local gossip. She always wears a hat that resembles a tea cosy. Other characters often find her annoying - Desmond is particularly antagonistic towards her. She often speaks about her ailments and the many medications she has to take, as well as having to prepare her husband's Cuthbert's red mullet. The couple has four children: three sons and a daughter, Merlene.
• Vince (Count Prince Miller) becomes a part-time assistant in the barbershop in the final series to replace Tony. He is also the drummer for The Georgetown Dreamers.
• Burt (Sol Raye) plays the electric guitar in The Georgetown Dreamers, along with Desmond, Porkpie, Vince, and, formerly, Sweetsticks.
• Andrew "Spider" Webb (Robert McKewley) is Sean's best friend after Series 3 and has an open crush on Gloria. He plays ragga music and is an entrepreneur; semi-famous under the name Spider Ranks, he eventually becomes semi-famous as a dancehall artist, although other characters criticise him for misogynistic and homophobic lyrics. Desmond and Shirley disapprove of him.
• Alex Reynolds (Chris Tummings) is Gloria's boyfriend from Series 4. He is a strict vegetarian and an abstract artist who works in various media. Gloria and Alex move in together towards the end of the series. It is revealed in the first episode of the Porkpie spin-off series that Alex and Gloria are still together.
• Bernie (Rhashan Stone) is the first friend that Sean made at university on his first day. He is openly gay.
• Ronni (Teohna Williams) is Gloria's best friend in Series 5 and 6.
• Ricky Flaxman (Dean Gatiss) is Tony's replacement in the final season. He gets the job as the new barber's assistant although he is underqualified, having only been a dog groomer, because Desmond owes his father a favour in exchange for supplying an alibi. Ricky moves into Gloria's room after she moved out to live with Alex. Through Season 6, Desmond teaches him about barbering.
• Sweetsticks is sometimes mentioned in the show although he never appears on screen. He was a member of The Georgetown Dreamers as their steel pan player and is often cited by Desmond and Porkpie as having been a ladies' man, a liar, and a cheat. He was revealed to be Lee's father.

Channel 4 DVD has released the first two series on DVD in the UK. Series One was released on 1 October 2007. Series Two was released on 14 April 2008.[10]

Visual Entertainment has begun releasing Desmond's on DVD in Canada. To date they have released the first four series of the show on DVD. Series 1 and 2 were released on 27 March 2007.[11] Series 3 was released on 3 November 2009.[12] On 2 March 2010, VEI released Desmond's- The Collection: Series One to Four, a seven-disc set featuring all episodes from the first four seasons.[13]

All six seasons are available to stream in the UK on the Channel 4 service All 4 and through the streaming services Amazon Prime and Netflix.