Diacylglycerol O-acyltransferase 2
Diacylglycerol O-acyltransferase 2 (DGAT2) is a protein that in humans is encoded by the DGAT2 gene. [5]
Function
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs.
The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.
References
- GRCh38: Ensembl release 89: ENSG00000062282 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000030747 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Diacylglycerol O-acyltransferase 2". Retrieved 2017-07-18.
Further reading
- Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y (2003). "A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice". Biochem. Biophys. Res. Commun. 310 (2): 296–302. doi:10.1016/j.bbrc.2003.09.015. PMID 14521909.
- Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML (2004). "Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells". J. Lipid Res. 45 (10): 1835–45. doi:10.1194/jlr.M300403-JLR200. PMID 15258194.
- Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007). "Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13". BMC Genet. 8: 17. doi:10.1186/1471-2156-8-17. PMC 1871603. PMID 17477860.
- Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007). "Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13". BMC Genet. 8: 17. doi:10.1186/1471-2156-8-17. PMC 1871603. PMID 17477860.
- Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ (2007). "Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis". J. Biol. Chem. 282 (29): 21005–14. doi:10.1074/jbc.M702871200. PMC 2254492. PMID 17504763.
- Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV (2007). "Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle". Am. J. Physiol. Endocrinol. Metab. 293 (6): E1772–81. doi:10.1152/ajpendo.00158.2007. PMID 17940217.
- Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008). "Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis". J. Lipid Res. 49 (11): 2283–301. doi:10.1194/jlr.R800018-JLR200. PMC 3837458. PMID 18757836.
- Kantartzis K, Machicao F, Machann J, Schick F, Fritsche A, Häring HU, Stefan N (2009). "The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans" (PDF). Clin. Sci. 116 (6): 531–7. doi:10.1042/CS20080306. PMID 18980578. S2CID 24593609.
- Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV (2009). "The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria". J. Biol. Chem. 284 (8): 5352–61. doi:10.1074/jbc.M805768200. PMC 2643492. PMID 19049983.
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