Diaminopyrimidine
Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.
![](../I/Iclaprim.svg.png.webp)
Iclaprim
![](../I/Trimethoprim.svg.png.webp)
Trimethoprim
They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim[1] and the antibiotics Iclaprim and trimethoprim).
Some have been patented as anti-cancer drugs.[2]
References
- http://aac.asm.org/cgi/content/full/45/12/3293 Archived 2008-08-29 at the Wayback Machine "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
- "Archived copy". Archived from the original on 2011-06-05. Retrieved 2009-01-05.
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: CS1 maint: archived copy as title (link)
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