Dimethylamine-corrinoid protein Co-methyltransferase
Dimethylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.249, mtbB (gene), dimethylamine methyltransferase) is an enzyme with systematic name dimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- dimethylamine + [Co(I) dimethylamine-specific corrinoid protein] [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine
| Dimethylamine-corrinoid protein Co-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.249 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in methanogenesis from dimethylamine.
References
- Wassenaar RW, Keltjens JT, van der Drift C, Vogels GD (May 1998). "Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro". European Journal of Biochemistry. 253 (3): 692–7. doi:10.1046/j.1432-1327.1998.2530692.x. PMID 9654067.
- Ferguson DJ, Gorlatova N, Grahame DA, Krzycki JA (September 2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". The Journal of Biological Chemistry. 275 (37): 29053–60. doi:10.1074/jbc.m910218199. PMID 10852929.
- Krzycki JA (October 2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Current Opinion in Chemical Biology. 8 (5): 484–91. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
External links
- Dimethylamine---corrinoid+protein+Co-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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