Dimethylhistidine N-methyltransferase

In enzymology, a dimethylhistidine N-methyltransferase (EC 2.1.1.44) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L-histidine
dimethylhistidine N-methyltransferase
Identifiers
EC no.2.1.1.44
CAS no.62213-53-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and Nalpha,Nalpha-dimethyl-L-histidine, whereas its two products are S-adenosylhomocysteine and Nalpha,Nalpha,Nalpha-trimethyl-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase. Other names in common use include dimethylhistidine methyltransferase, histidine-alpha-N-methyltransferase, S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine, and alpha-N-methyltransferase.

References

    • Ishikawa Y, Melville DB (1970). "The enzymatic alpha-N-methylation of histidine". J. Biol. Chem. 245 (22): 5967–73. PMID 5484456.


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