Doc – Nelle tue mani

Professor Andrea Fanti is a brilliant and famous doctor working at the Policlinico Ambrosiano hospital of Milan, where he is the chief of the internal medicine department. At the same time, he is also arrogant, painstaking and narcissistic.

Fanti thinks that doctors should not trust patients, as they lie. Consequently, he only follows his instinct and trusts his team, especially his assistant Giulia Giordano, a doctor with whom he has a secret relationship.

One day, the father of Giovanni Pavesi, a young boy died in Fanti's ward following a mistake (he was given the wrong medicine, the Satonal, due to a homonymy error), waits for Fanti to end his shift at the hospital and shoots him in the head. Despite the doctor does not die, he suffers from an irreversible prefrontal trauma, which causes him to forget the previous 12 years. Indeed, when Fanti wakes up from the coma, he believes that it is June 2008 instead of 2020 and his last memory is him coming home after signing his first contract with the Policlinico Ambrosiano. Forgetting most of the staff he used to work with, he turns from an authoritative doctor into a patient of the hospital.

Thrown into a present he sometimes struggles to understand, obliged to start over most of his life and to deal with relevant trauma like his child's death and the separation from his wife (which he forgot), he perceives his loved ones as strangers. As a consequence, the hospital becomes the only place where Andrea feels really at home and where he can try to build a new private and working future.

No more able to be the chief of the department he used to be in charge of, he comes back to work as a "doctor with limitations", that is a kind of assistant for young residents, who nickname him Doc, and uses empathy to interact with patients and help solve their medical issues. In the meantime, he starts a psychological journey with doctor Sardoni, a longtime friend and colleague of his.[4][5][6]

Set in an unspecified future, COVID-19 critical stage has ended and the Policlinico Ambrosiano comes back to normal activity.

Several flashbacks allow us to understand what happened during the acute phase of the COVID-19 pandemic in Italy. Many wards were converted to face the emergency, including the internal medicine department. However, the hospital had limited resources and people to cope with thousands of patients in a very short time, so, once the emergency ends, the high number of dead doctors and patients leads to an investigation by both the Italian Magistrates' court and the hospital itself, involving all the medical staff, medical director Agnese Tiberi, Andrea Fanti and his team.

Among the victims of COVID-19, there is Lorenzo Lazzarini, a member of Fanti's team later identified as the patient zero, the one who unintentionally introduced the virus in the Policlinico: only his colleagues know the truth about him being the index case and they keep the secret to honour his memory. However, his death, which occurred under unclear circumstances, is also a matter of investigation.

In the meantime, Agnese is suspended from her role as director due to the investigation about the department he managed during the pandemic and starts working as a senior doctor in the ward she used to belong to, which doctor Sandri manages. The lawyer Caruso, also chief of the administrative department, is appointed as the new medical director with the aim of finding out the truth about how the doctors tackled the pandemic emergency.

At the same time, doctor Cecilia Tedeschi, famous virologist and scholar of infetious diseases, is appointed as chief of the internal medicine department, a vacant role after the imprisonment of professor Sardoni and temporarily held by doctor Giordano during the pandemic. Tedeschi is also a former Agnese and Andrea's university mate and was once in love with Andrea, who did not reciprocate her feelings.

Tedeschi secretly wants to turn the internal medicine department into an infectious diseases department with Caruso's help.

Trying to save his department, keep his team united and protect everyone from the investigation, Andrea decides to get his role as chief of the department back, facing several exams intended to certify his eligibility. While doing so, Andrea also needs to deal with Caruso, who does not want him to manage that department for some unknown reasons.[4][6][7]

• Luca Argentero as Dr. Andrea Fanti
• Matilde Gioli as Dr. Giulia Giordano
• Pierpaolo Spollon as Dr. Riccardo Bonvenga
• Raffaele Esposito as Dr. Marco Sardoni (season 1)
• Sara Lazzaro as Dr. Agnese Tiberi
• Gianmarco Saurino as Dr. Lorenzo Lazzarini (season 1; recurring season 2)
• Simona Tabasco as Dr. Elisa Russo
• Alberto Malanchino as Dr. Gabriel Kidane
• Silvia Mazzieri as Dr. Alba Patrizi (season 1-2)
• Beatrice Grannò as Carolina Fanti
• Elisa Di Eusanio as Nurse Teresa Maraldi
• Giovanni Scifoni as Dr. Enrico Sandri
• Alice Arcuri as Dr. Cecilia Tedeschi (season 2-present)
• Marco Rossetti as Dr. Damiano Cesconi (season 2-present)
• Gaetano Bruno as Dr. Edoardo Valenti (season 2-present)

• Simone Gandolfo as Davide
• Mariarosa Russo as Irene Ceraldo (season 1)
• Pia Lanciotti as Dr. Fabrizia Martelli (season 1-2)
• Giusy Buscemi as Dr. Lucia Ferrari (season 2)
• Massimo Rigo as Umberto Caruso (season 2)
• Lorenzo Frediani as Father Massimo (season 2)

• Valeria Fabrizi as Tilde Ravelli
• Fiammetta Cicogna as Vittoria
• Alberto Molinari as Edoardo Grotti
• Ilaria Spada as Serena Ruffo
• Giacomo Poretti as Giacomo