Docking protein 6

Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. [5]

DOK6
Identifiers
AliasesDOK6, DOK5L, HsT3226, docking protein 6
External IDsOMIM: 611402 MGI: 3639495 HomoloGene: 45143 GeneCards: DOK6
Orthologs
SpeciesHumanMouse
Entrez

220164

623279

Ensembl

ENSG00000206052

ENSMUSG00000073514

UniProt

Q6PKX4

Q2MHE5

RefSeq (mRNA)

NM_152721

NM_001039173

RefSeq (protein)

NP_689934

NP_001034262

Location (UCSC)Chr 18: 69.4 – 69.85 MbChr 18: 89.31 – 89.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).

References

  1. GRCh38: Ensembl release 89: ENSG00000206052 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000073514 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.

Further reading

  • Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
  • Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMID 20210798. S2CID 11769638.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.