Donna R. Maglott

Donna R. Maglott is a staff scientist at the National Center for Biotechnology Information known for her research on large-scale genomics projects, including the mouse genome and development of databases required for genomics research.

Donna R. Maglott
Alma materUniversity of Michigan
Scientific career
InstitutionsNational Center for Biotechnology Information
ThesisThe structure and function of the 50S ribosome of Escherichia coli (1970)

Education and career

Maglott earned her Ph.D. in 1970 from the University of Michigan where she worked on the 50S ribosome in the bacterium Escherichia coli.[1] She held an academic position at Howard University; and then moved to the American Type Culture Center in 1986 where she began establishing databases needed for genomic research.[2][3] She started at the National Center for Biotechnology Information (NCBI) in 1998.[4]

Research

While at Howard University, Maglott worked on protein synthesis during early development of sea urchins.[5][6] At ATCC, she worked on repositories holding clone and genomic information[7][8] and began research using genomic tools to investigate information on human chromosomes.[9][10] In 2000, Maglott worked with Kim D. Pruitt to introduce RefSeq, a web-based resource for gene-based information that is hosted by NCBI[11][12] and has been updated over the years.[13][14] She has also been involved in the development of other databases at NCBI including Entrez Gene,[15][16] ClinVar,[17][18] STS markers, Conserved CoDing Sequences (CCDS), Map Viewer, RefSeqGene, the NIH Genetic Testing Registry (GTR), MedGen, and ClinVar.[4] Large-scale genomics projects that Margott has worked on include the rat genome database,[19] and the mouse genome[20][21] and transcriptome.[22] In 2006, Maglott was a part of the team analyzing the genome of the sea urchin, Strongylocentrotus purpuratus, which was the first genome obtained for a motile marine invertebrate.[23][24]

Selected publications

References
  1. Maglott, Donna Rae Schneider (1970). The structure and function of the 50S ribosome of Escherichia coli (Thesis). Ann Arbor - Mich. OCLC 633231185.
  2. "Center for Bioinformatics and Computational Biology". www.cbcb.umd.edu. 2006. Archived from the original on 2007-08-17. Retrieved 2021-10-02.
  3. "Donna Maglott, PhD - ClinGen | Clinical Genome Resource". 2017-07-10. Archived from the original on 2017-07-10. Retrieved 2021-10-02.
  4. "Human Variome Project". www.humanvariomeproject.org. Retrieved 2016-12-18.
  5. Maglott, D.R. (1985). "Dissociation of cells from sea urchin embryos alters the synthesis of actins and other proteins". Cell Differentiation. 17 (1): 29–43. doi:10.1016/0045-6039(85)90535-4. PMID 3875415.
  6. Maglott, D.R. (1985). "Two-dimensional electrophoretic analysis of major phosphoproteins of the sea urchin, Arbacia punctulata". Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 80 (3): 513–516. doi:10.1016/0305-0491(85)90282-2. PMID 4006443.
  7. Maglott, Donna R.; Nierman, William C. (1990-11-01). "Clone and genomic repositories at the American Type Culture Collection". Genomics. 8 (3): 601–605. doi:10.1016/0888-7543(90)90054-X. ISSN 0888-7543. PMID 1981058.
  8. Maglott, Donna R.; Nierman, William C. (1991). "Mammalian probes and libraries at the ATCC". Mammalian Genome. 1 (1): 59–64. doi:10.1007/BF00350848. ISSN 0938-8990. PMID 1794047. S2CID 12336955.
  9. Scott Durkin, A.; Maglott, Donna R.; Nierman, William C. (1992-11-01). "Chromosomal assignment of 38 human brain expressed sequence tags (ESTs) by analyzing fluorescently labeled PCR products from hybrid cell panels". Genomics. 14 (3): 808–810. doi:10.1016/S0888-7543(05)80194-6. ISSN 0888-7543. PMID 1427913.
  10. Schmidt, Valentina A.; Nierman, William C.; Maglott, Donna R.; Cupit, Lisa D.; Moskowitz, Keith A.; Wainer, Jean Ann; Bahou, Wadie F. (1998). "The Human Proteinase-activated Receptor-3 (PAR-3) Gene". Journal of Biological Chemistry. 273 (24): 15061–15068. doi:10.1074/jbc.273.24.15061. ISSN 0021-9258. PMID 9614115.
  11. Maglott, D. R. (2000-01-01). "NCBI's LocusLink and RefSeq". Nucleic Acids Research. 28 (1): 126–128. doi:10.1093/nar/28.1.126. PMC 102393. PMID 10592200.
  12. Pruitt, Kim D.; Katz, Kenneth S.; Sicotte, Hugues; Maglott, Donna R. (2000). "Introducing RefSeq and LocusLink: curated human genome resources at the NCBI". Trends in Genetics. 16 (1): 44–47. doi:10.1016/S0168-9525(99)01882-X. PMID 10637631.
  13. Pruitt, K. D. (2001-01-01). "RefSeq and LocusLink: NCBI gene-centered resources". Nucleic Acids Research. 29 (1): 137–140. doi:10.1093/nar/29.1.137. PMC 29787. PMID 11125071.
  14. Pruitt, K. D.; Tatusova, T.; Maglott, D. R. (2007-01-03). "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins". Nucleic Acids Research. 35 (Database): D61–D65. doi:10.1093/nar/gkl842. ISSN 0305-1048. PMC 1716718. PMID 17130148.
  15. Maglott, D. (2004-12-17). "Entrez Gene: gene-centered information at NCBI". Nucleic Acids Research. 33 (Database issue): D54–D58. doi:10.1093/nar/gki031. ISSN 1362-4962. PMC 539985. PMID 15608257.
  16. Maglott, D.; Ostell, J.; Pruitt, K. D.; Tatusova, T. (2011-01-01). "Entrez Gene: gene-centered information at NCBI". Nucleic Acids Research. 39 (Database): D52–D57. doi:10.1093/nar/gkq1237. ISSN 0305-1048. PMC 3013746. PMID 21115458.
  17. Landrum, Melissa J; Lee, Jennifer M; Benson, Mark; Brown, Garth R; Chao, Chen; Chitipiralla, Shanmuga; Gu, Baoshan; Hart, Jennifer; Hoffman, Douglas; Jang, Wonhee; Karapetyan, Karen (2018-01-04). "ClinVar: improving access to variant interpretations and supporting evidence". Nucleic Acids Research. 46 (D1): D1062–D1067. doi:10.1093/nar/gkx1153. ISSN 0305-1048. PMC 5753237. PMID 29165669.
  18. Landrum, Melissa J.; Lee, Jennifer M.; Riley, George R.; Jang, Wonhee; Rubinstein, Wendy S.; Church, Deanna M.; Maglott, Donna R. (2014). "ClinVar: public archive of relationships among sequence variation and human phenotype". Nucleic Acids Research. 42 (D1): D980–D985. doi:10.1093/nar/gkt1113. ISSN 0305-1048. PMC 3965032. PMID 24234437.
  19. Twigger, S. (2002-01-01). "Rat Genome Database (RGD): mapping disease onto the genome". Nucleic Acids Research. 30 (1): 125–128. doi:10.1093/nar/30.1.125. PMC 99132. PMID 11752273.
  20. Mouse Genome Sequencing Consortium (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520–562. Bibcode:2002Natur.420..520W. doi:10.1038/nature01262. ISSN 0028-0836. PMID 12466850.
  21. Hudson, Thomas J.; Church, Deanna M.; Greenaway, Simon; Nguyen, Huy; Cook, April; Steen, Robert G.; Van Etten, William J.; Castle, Andrew B.; Strivens, Mark A.; Trickett, Pamela; Heuston, Christine (2001). "A radiation hybrid map of mouse genes". Nature Genetics. 29 (2): 201–205. doi:10.1038/ng1001-201. ISSN 1061-4036. PMID 11586302. S2CID 27643522.
  22. The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team* (2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs". Nature. 420 (6915): 563–573. Bibcode:2002Natur.420..563O. doi:10.1038/nature01266. ISSN 0028-0836. PMID 12466851. S2CID 4347839.
  23. Sea Urchin Genome Sequencing Consortium; Sodergren, E.; Weinstock, G. M.; Davidson, E. H; Cameron, R. A.; Gibbs, R. A.; Angerer, R. C.; Angerer, L. M.; Arnone, M. I.; Burgess, D. R.; Burke, R. D. (2006-11-10). "The Genome of the Sea Urchin Strongylocentrotus purpuratus". Science. 314 (5801): 941–952. Bibcode:2006Sci...314..941S. doi:10.1126/science.1133609. ISSN 0036-8075. PMC 3159423. PMID 17095691.
  24. Livingston, B.T.; Killian, C.E.; Wilt, F.; Cameron, A.; Landrum, M.J.; Ermolaeva, O.; Sapojnikov, V.; Maglott, D.R.; Buchanan, A.M.; Ettensohn, C.A. (2006). "A genome-wide analysis of biomineralization-related proteins in the sea urchin Strongylocentrotus purpuratus". Developmental Biology. 300 (1): 335–348. doi:10.1016/j.ydbio.2006.07.047. PMID 16987510.
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