EAF1

EAF1
Identifiers
Aliases	EAF1, ELL associated factor 1
External IDs	OMIM: 608315 MGI: 1921677 HomoloGene: 12561 GeneCards: EAF1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	15,450,635 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	31,231,815 bp[2]
RNA expression pattern
	Top expressed in
	amniotic fluid; ; islet of Langerhans; ; monocyte; ; secondary oocyte; ; lower lobe of lung; ; palpebral conjunctiva; ; pancreatic epithelial cell; ; prefrontal cortex; ; ganglionic eminence; ; bone marrow;
	Top expressed in
	olfactory epithelium; ; primitive streak; ; superior cervical ganglion; ; thymus; ; hair follicle; ; hand; ; abdominal wall; ; skin of abdomen; ; lip; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Cajal body; nuclear speck; transcription elongation factor complex; super elongation complex; intracellular membrane-bounded organelle; intercellular bridge; nucleus; nucleoplasm; nuclear body;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	85403
	74427
	ENSG00000144597
	ENSMUSG00000021890
	Q96JC9
	Q9D4C5
	NM_033083
	NM_028932
	NP_149074
	NP_083208
	Wikidata
View/Edit Human	View/Edit Mouse

ELL-associated factor 1 is a protein that, in humans, is encoded by the EAF1 gene.[5][6] It is part of the EAF family of proteins.

References

GRCh38: Ensembl release 89: ENSG00000144597 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021890 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein". Blood. 98 (1): 201–9. doi:10.1182/blood.V98.1.201. PMID 11418481. S2CID 2577367.
"Entrez Gene: EAF1 ELL associated factor 1".

Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003). "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia". Molecular Biology of the Cell. 14 (4): 1517–28. doi:10.1091/mbc.E02-07-0394. PMC 153119. PMID 12686606.
Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proceedings of the National Academy of Sciences of the United States of America. 102 (29): 10094–8. Bibcode:2005PNAS..10210094K. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
Xiao W, Jiang F, Wang Z (January 2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". The Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057. S2CID 32749490.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Jiang F, Ai J, Xiao W, Wang Z (August 2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Letters. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.

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