Epstein–Barr virus nuclear antigen 3

The Epstein–Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein–Barr virus. A typical EBV genome contains three such proteins:[1]

  • EBNA-3A (P12977, EBNA-3; BLRF3-BERF1)
  • EBNA-3B (P03203, EBNA-4; BERF2A-BERF2B)
  • EBNA-3C (P03204, EBNA-6, EBNA-4B; BERF3-BERF4)
Epstein–Barr virus nuclear antigen 3
Identifiers
SymbolEBV-NA3
PfamPF05009
InterProIPR007706
SCOP21m05 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

These genes also bind the host RBP-Jκ protein.[2]

EBNA-3C can recruit a ubiquitin ligase and has been shown to target cell-cycle regulators such as retinoblastoma protein (pRb).[3][4]

References

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.