EI24

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.[5][6][7]

EI24
Identifiers
AliasesEI24, EPG4, PIG8, TP53I8, autophagy associated transmembrane protein, EI24 autophagy associated transmembrane protein
External IDsOMIM: 605170 MGI: 108090 HomoloGene: 3588 GeneCards: EI24
Orthologs
SpeciesHumanMouse
Entrez

9538

13663

Ensembl

ENSG00000149547

ENSMUSG00000062762

UniProt

O14681

Q61070

RefSeq (mRNA)

NM_001007277
NM_001290135
NM_004879
NM_001330419

NM_001199494
NM_007915

RefSeq (protein)

NP_001277064
NP_001317348
NP_004870

NP_001186423
NP_031941

Location (UCSC)Chr 11: 125.57 – 125.58 MbChr 9: 36.69 – 36.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000149547 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062762 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gu Z, Flemington C, Chittenden T, Zambetti GP (Jan 2000). "ei24, a p53 response gene involved in growth suppression and apoptosis". Mol Cell Biol. 20 (1): 233–41. doi:10.1128/MCB.20.1.233-241.2000. PMC 85079. PMID 10594026.
  6. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID 9305847. S2CID 4429638.
  7. "Entrez Gene: EI24 etoposide induced 2.4 mRNA".

Further reading


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