ELAV-like protein 1

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.[5][6]

ELAVL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELAVL1, ELAV1, HUR, Hua, MelG, ELAV like RNA binding protein 1, HuR
External IDsOMIM: 603466 MGI: 1100851 HomoloGene: 20367 GeneCards: ELAVL1
Orthologs
SpeciesHumanMouse
Entrez

1994

15568

Ensembl

ENSG00000066044

ENSMUSG00000040028

UniProt

Q15717

P70372

RefSeq (mRNA)

NM_001419

NM_010485

RefSeq (protein)

NP_001410

NP_034615

Location (UCSC)Chr 19: 7.96 – 8.01 MbChr 8: 4.34 – 4.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000066044 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040028 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ma WJ, Cheng S, Campbell C, et al. (Jun 1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein". J Biol Chem. 271 (14): 8144–8151. doi:10.1074/jbc.271.14.8144. PMID 8626503.
  6. Ma WJ, Furneaux H (Feb 1997). "Localization of the human HuR gene to chromosome 19p13.2". Hum Genet. 99 (1): 32–33. doi:10.1007/s004390050305. PMID 9003489. S2CID 32509747.
  7. "Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)".
  8. Brenda Janice Sánchez; Souad Mubaid; Sandrine Busque; et al. (22 February 2023). "The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis". Nucleic Acids Research. 51 (3): 1375–1392. doi:10.1093/nar/gkac1245. hdl:10754/687126. PMC 9943665. PMID 36629268.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human ELAV-like protein 1


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