ELL (gene)

RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene.[5][6][7]

ELL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELL, C19orf17, ELL1, MEN, PPP1R68, elongation factor for RNA polymerase II
External IDsOMIM: 600284 MGI: 109377 HomoloGene: 4762 GeneCards: ELL
Orthologs
SpeciesHumanMouse
Entrez

8178

13716

Ensembl

ENSG00000105656

ENSMUSG00000070002

UniProt

P55199

O08856

RefSeq (mRNA)

NM_006532

NM_007924

RefSeq (protein)

NP_006523

NP_031950

Location (UCSC)Chr 19: 18.44 – 18.52 MbChr 8: 70.99 – 71.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

ELL (gene) has been shown to interact with P53.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000105656 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000070002 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (Jan 1995). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proc Natl Acad Sci U S A. 91 (25): 12110–4. Bibcode:1994PNAS...9112110T. doi:10.1073/pnas.91.25.12110. PMC 45386. PMID 7991593.
  6. Shilatifard A, Lane WS, Jackson KW, Conaway RC, Conaway JW (Apr 1996). "An RNA polymerase II elongation factor encoded by the human ELL gene". Science. 271 (5257): 1873–6. Bibcode:1996Sci...271.1873S. doi:10.1126/science.271.5257.1873. PMID 8596958. S2CID 46101044.
  7. "Entrez Gene: ELL elongation factor RNA polymerase II".
  8. Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, Hatakeyama M (Jun 1999). "Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53". J. Biol. Chem. 274 (24): 17003–10. doi:10.1074/jbc.274.24.17003. PMID 10358050.

Further reading


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