ELMO3

Engulfment and cell motility 3, also known as ELMO3, is a human gene.[1][2]

engulfment and cell motility 3
Identifiers
SymbolELMO3
Alt. symbolsCED12, FLJ13824
NCBI gene79767
HGNC17289
OMIM606422
RefSeqNM_024712
UniProtQ96BJ8
Other data
LocusChr. 16 q22.1
Search for
StructuresSwiss-model
DomainsInterPro

The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 (DOCK1) protein to promote phagocytosis and effect cell shape changes.[1]

References

  1. "Entrez Gene: ELMO3 engulfment and cell motility 3".
  2. Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS (October 2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration" (PDF). Cell. 107 (1): 27–41. doi:10.1016/S0092-8674(01)00520-7. PMID 11595183. S2CID 15232864.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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