EMCN

Endomucin is a protein that in humans is encoded by the EMCN gene.[5][6][7] Endomucin is a marker for endothelial cells[8] and hematopoietic stem cells.[9]

EMCN
Identifiers
AliasesEMCN, EMCN2, MUC14, endomucin
External IDsOMIM: 608350 MGI: 1891716 HomoloGene: 9438 GeneCards: EMCN
Orthologs
SpeciesHumanMouse
Entrez

51705

59308

Ensembl

ENSG00000164035

ENSMUSG00000054690

UniProt

Q9ULC0

Q9R0H2

RefSeq (mRNA)

NM_001159694
NM_016242

NM_001163522
NM_016885

RefSeq (protein)

NP_001153166
NP_057326

NP_001156994
NP_058581

Location (UCSC)Chr 4: 100.4 – 100.88 MbChr 3: 137.05 – 137.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.[5][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000164035 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054690 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.
  6. Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
  7. "Entrez Gene: EMCN endomucin".
  8. Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288 (1): 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.
  9. Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.

Further reading


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