ENTPD2

Ectonucleoside triphosphate diphosphohydrolase 2 is an enzyme that in humans is encoded by the ENTPD2 gene.[5][6]

ENTPD2
Identifiers
AliasesENTPD2, CD39L1, NTPDase-2, ectonucleoside triphosphate diphosphohydrolase 2
External IDsOMIM: 602012 MGI: 1096863 HomoloGene: 20333 GeneCards: ENTPD2
Orthologs
SpeciesHumanMouse
Entrez

954

12496

Ensembl

ENSG00000054179

ENSMUSG00000015085

UniProt

Q9Y5L3

O55026

RefSeq (mRNA)

NM_001246
NM_203468

NM_009849

RefSeq (protein)

NP_001237
NP_982293

NP_033979

Location (UCSC)Chr 9: 137.05 – 137.05 MbChr 2: 25.29 – 25.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants.[6]

It has been shown, by scientists from the University of Warwick, that E-NTPDase2 stimulates the growth of the eye: by testing the enzyme on tadpoles, the tadpoles were found to develop extra eyes on their body.

References

  1. GRCh38: Ensembl release 89: ENSG00000054179 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015085 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
  6. "Entrez Gene: ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2".

Further reading


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