ENTPD3

ENTPD3
Identifiers
Aliases	ENTPD3, CD39L3, HB6, NTPDase-3, ectonucleoside triphosphate diphosphohydrolase 3
External IDs	OMIM: 603161 MGI: 1321386 HomoloGene: 68171 GeneCards: ENTPD3
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	40,428,744 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	120,397,393 bp[2]
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; periodontal fiber; ; middle temporal gyrus; ; parotid gland; ; putamen; ; tibia; ; caudate nucleus; ; minor salivary gland; ; mucosa of urinary bladder; ; body of pancreas;
	Top expressed in
	molar; ; islet of Langerhans; ; body of femur; ; lesser wing of sphenoid bone; ; dermal bone; ; human mandible; ; lacrimal gland; ; otolith organ; ; calvaria; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; hydrolase activity; ATP binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	nucleoside triphosphate catabolic process; nucleoside diphosphate catabolic process; nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	956
	215446
	ENSG00000168032
	ENSMUSG00000041608
	O75355
	Q8BFW6
	NM_001248; NM_001291960; NM_001291961
	NM_178676
	NP_001239; NP_001278889; NP_001278890
	NP_848791
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.[5][6]

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.[6]

References

GRCh38: Ensembl release 89: ENSG00000168032 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041608 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
"Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".

Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). "Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists". Biochem. Pharmacol. 74 (10): 1524–34. doi:10.1016/j.bcp.2007.07.033. PMID 17727821.
Ivanenkov VV, Meller J, Kirley TL (2005). "Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling". Biochemistry. 44 (25): 8998–9012. doi:10.1021/bi047487z. PMID 15966724.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). "Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions". Biochemistry. 40 (13): 3943–50. doi:10.1021/bi002711f. PMID 11300774.
Smith TM, Lewis Carl SA, Kirley TL (1999). "Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase". Biochemistry. 38 (18): 5849–57. doi:10.1021/bi990171k. PMID 10231536.
Smith TM, Kirley TL (1998). "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1". Biochim. Biophys. Acta. 1386 (1): 65–78. doi:10.1016/s0167-4838(98)00063-6. PMID 9675246.
Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm. Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168032 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041608 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9676430-5] Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.

[entrez-6] "Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".

ENTPD3

References

Further reading