ERP29

Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein that in humans is encoded by the ERP29 gene.[5]

ERP29
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesERP29, C12orf8, ERp28, ERp31, HEL-S-107, PDI-DB, PDIA9, endoplasmic reticulum protein 29
External IDsOMIM: 602287 MGI: 1914647 HomoloGene: 4963 GeneCards: ERP29
Orthologs
SpeciesHumanMouse
Entrez

10961

67397

Ensembl

ENSG00000089248

ENSMUSG00000029616

UniProt

P30040

P57759

RefSeq (mRNA)

NM_006817
NM_001034025

NM_026129

RefSeq (protein)

NP_001029197
NP_006808

NP_080405

Location (UCSC)Chr 12: 112.01 – 112.02 MbChr 5: 121.57 – 121.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

ERp29 is a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide-isomerase family.[6] However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase.[6] The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000089248 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029616 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ERP29 endoplasmic reticulum protein 29".
  6. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading


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