EXTL2

Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene.[5][6][7] EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)

EXTL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEXTL2, EXTR2, exostosin-like glycosyltransferase 2, exostosin like glycosyltransferase 2
External IDsOMIM: 602411 MGI: 1889574 HomoloGene: 1102 GeneCards: EXTL2
Orthologs
SpeciesHumanMouse
Entrez

2135

58193

Ensembl

ENSG00000162694

ENSMUSG00000027963

UniProt

Q9UBQ6

Q9ES89

RefSeq (mRNA)

NM_001033025
NM_001261440
NM_001261441
NM_001261442
NM_001439

NM_001163514
NM_001163515
NM_021388

RefSeq (protein)

NP_001028197
NP_001248369
NP_001248370
NP_001248371
NP_001430

NP_001156986
NP_001156987
NP_067363

Location (UCSC)Chr 1: 100.87 – 100.9 MbChr 3: 115.8 – 115.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000162694 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027963 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
  6. Sobhany M, Dong J, Negishi M (Jun 2005). "Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase". J Biol Chem. 280 (25): 23441–5. doi:10.1074/jbc.M413379200. PMID 15831490.
  7. "Entrez Gene: EXTL2 exostoses (multiple)-like 2".

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Exostosin-like 2


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