Brain of Albert Einstein

Harvey had reported that Einstein had no parietal operculum in either hemisphere,[15] but this finding has been disputed.[16] Photographs of the brain show an enlarged Sylvian fissure. In 1999, further analysis by a team at McMaster University in Hamilton, Ontario revealed that his parietal operculum region in the inferior frontal gyrus in the frontal lobe of the brain was vacant. Also absent was part of a bordering region called the lateral sulcus (Sylvian fissure). Researchers at McMaster University speculated that the vacancy may have enabled neurons in this part of his brain to communicate better. "This unusual brain anatomy...[missing part of the Sylvian fissure]... may explain why Einstein thought the way he did," said Professor Sandra Witelson who led the research published in The Lancet. This study was based on photographs of the whole brain made at autopsy in 1955 by Harvey and not a direct examination of the brain. Einstein himself claimed that he thought visually rather than verbally. Professor Laurie Hall of Cambridge University, commenting on the study, said, "To say there is a definite link is one bridge too far, at the moment. So far, the case isn't proven. But magnetic resonance and other new technologies are allowing us to start to probe those very questions."[17]

In the 1980s, University of California, Berkeley professor Marian Diamond received four sections of the cortical association regions of the superior prefrontal and inferior parietal lobes in the right and left hemispheres of Albert Einstein's brain from Thomas Harvey. In 1984, Marian Diamond and her associates were the first ever to publish research on the brain of Albert Einstein.[18] She compared the ratio of glial cells in Einstein's brain with that of the preserved brains of 11 other males. (Glial cells provide support and nutrition in the brain, form myelin, and participate in signal transmission, and are the other integral component of the brain, besides the neurons.) Dr. Diamond's laboratory made thin sections of Einstein's brain, each 6 micrometers thick. They then used a microscope to count the cells. Einstein's brain had more glial cells relative to neurons in all areas studied, but only in the left inferior parietal area was the difference statistically significant. This area is part of the association cortex, regions of the brain responsible for incorporating and synthesizing information from multiple other brain regions. A stimulating environment can increase the proportion of glial cells and the high ratio could possibly result from Einstein's life studying stimulating scientific problems.[19] [20] The limitation that Diamond admits in her study is that she had only one Einstein to compare with 11 brains of normal intelligence individuals. S. S. Kantha of the Osaka Bioscience Institute criticized Diamond's study, as did Terence Hines of Pace University.[4] Other issues related to Diamond's study point out glial cells continue dividing as a person ages and although Einstein's brain was 76, it was compared to brains that averaged 64 in age (eleven male brains, 47–80 years of age). Diamond in her landmark study "On the Brain of a Scientist: Albert Einstein" noted that the 11 male individuals whose brains were used in her control base had died from nonneurologically related diseases. She also noted that "Chronological age is not necessarily a useful indicator in measuring biological systems. Environmental factors also play a strong role in modifying the conditions of the organism. One major problem in dealing with human specimens is that they do not come from controlled environments."[21]

Dr. Dahlia Zaidel of the University of California, Los Angeles, examined two slices of Albert Einstein's brain containing the hippocampus in 2001. The hippocampus is a subcortical brain structure that plays an important role in learning and memory. The neurons on the left side of the hippocampus were found to be significantly larger than those on the right, and when compared with normal brain slices of the same area in ordinary people, there was only minimal, inconsistent asymmetry in this area. "The larger neurons in the left hippocampus, Zaidel noted, imply that Einstein's left brain may have had stronger nerve cell connections between the hippocampus and another part of the brain called the neocortex than his right. The neocortex is where detailed, logical, analytical and innovative thinking takes place, Zaidel noted in a prepared statement."[22][23]

A study published in the journal Brain[24] in September 2013 analyzed Einstein's corpus callosum—a large bundle of fibers that connects the two cerebral hemispheres and facilitates interhemispheric communication in the brain—using a novel technique that allowed for a higher resolution measurement of the fiber thickness. Einstein's corpus callosum was compared to two sample groups: 15 brains of elderly people and 52 brains from people aged 26. Einstein was 26 in 1905, his Annus Mirabilis (Miracle Year). The findings show that Einstein had more extensive connections between certain parts of his cerebral hemispheres compared to both younger and older control group brains.[25]

A study, "The cerebral cortex of Albert Einstein: a description and preliminary analysis of unpublished photographs",[16] was published on November 16, 2012, in the journal Brain. Dean Falk, an evolutionary anthropologist at Florida State University, led the study - which analyzed 14 recently discovered photographs - and described the brain: "Although the overall size and asymmetrical shape of Einstein's brain were normal, the prefrontal, somatosensory, primary motor, parietal, temporal and occipital cortices were extraordinary."[26] There was a fourth ridge (apart from the three normal people have) in Einstein's mid-frontal lobe involved in making plans and working memory. The parietal lobes were markedly asymmetrical and a feature in Einstein's primary motor cortex may have been associated with his musical ability.[19]

Another study led by Shanghai-based East China Normal University's Department of Physics, "The Corpus Callosum of Albert Einstein's Brain: Another Clue to His High Intelligence", published in the journal Brain on September 24, 2013, showed a new technique to conduct the study, which is the first to detail Einstein's corpus callosum, the brain's largest bundle of fibers that connects the two cerebral hemispheres and facilitates interhemispheric communication.[27] Einstein's corpus callosum was thicker than those in control groups, possibly indicating better cooperation between the hemispheres. Scientists currently cannot tell how far the unusual features above were innate or how far they were due to Einstein's devoting his life to higher thought.

Publication bias may have influenced published results, which means that results showing differences between Einstein's brain and other brains tend to get published while results showing that in many respects Einstein's brain was like other brains tend to be neglected. Researchers knew which brain was Einstein's and which were controls, allowing possible conscious or unconscious bias and preventing impartial research.

Neurologist Terence Hines of Pace University is strongly critical of the studies and has stated that they are flawed. Hines maintains that all human brains are unique and different from others in some ways. Therefore, assuming unique features in Einstein's brain were connected with his genius, in Hines' opinion, goes beyond the evidence. He argues further that correlating unusual brain features with any characteristic requires studying many brains with those features, and says that scanning the brains of many very capable scientists would be better research than investigating the brains of just one or two geniuses.[19][28]