Ek Nayi Chhoti Si Zindagi

The story portrays the lives of two orphan girls, Isha and Ira who do not give up despite facing many hardships in life. Their mother died after Ira's birth and their father has to give them up because he is marrying someone else due to financial issues. He sends them to live in an orphanage with Devki and her brother Bhola.

At first, Isha and Ira are disliked by the kids at the orphanage because they escaped and the others had to starve, but Isha comes back because of Ira's declining health and injured leg. Devki constantly tries to separate the sisters by telling Ira bad stuff about Isha. Also, Isha finds out that Tinnu (a boy whom was helped by Isha and Ira when he once escaped the orphanage just like them, but was later caught by Bhola) is in the dark room and he had to starve because he helped Isha escape.

Meanwhile, Vrinda, the eldest and in charge of all the children, hates Isha because she causes a lot of trouble for them. But one day, when a guy named Arjun comes to deliver food, he meets Vrinda. They become friends and eventually fall in love. Bhola finds out and warns Vrinda. To get revenge, Vrinda mixes spices in Bhola's breakfast. Bhola tells Devki and threatens Isha to tell the truth. Devki says that she will accept any condition if she says who did it. Isha takes the blame and tells Devki to release Tinnu, who has become ill. Thakur and Fatima begin liking Isha but Vrinda and Cutting are still upset. Thakur, Fatima, and Isha try to take care of Tinnu but their efforts are in vain. Isha collects money and the kids help her. Vrinda comes, wanting to help and that prove she's better than Isha, so they tell Vrinda to try to convince Devki to get a doctor. The doctor comes and cures Tinnu.

A friendship begins between Isha and Vrinda, but Devki ruins it as she degrades Vrinda and announces Isha as the new manager for the kids, making Vrinda to hate her more. Arjun disguises himself as a famous businessman on the pretence of that wanting to adopt Vrinda. He talks to Vrinda alone and they both confess their love to each other. Bhola finds out that that man was Arjun and tells Devki. Isha warns Vrinda about it and Arjun leaves, she covers up the ordeal. Devki tells her men to check all of Vrinda's belongings and a letter that Arjun wrote to Vrinda falls out and Bhola sees this. When Devki is about to take it, Isha takes it first and eats it. When Devki is about to beat Isha, Ira bites her arm. Devki tries to hit Ira but Isha stops her. Isha tells her that while she is here she will change everything. Devki is embarrassed and leaves. Vrinda apologizes to Isha for being mean to her and they both become friends.

Outside, Tinnu sees Bhola and Devki talking to a foreigner. After the foreigner leaves, Devki tells the kids that she is sorry and tells them that they could do whatever they want to. Tinnu suspects her and tells Isha and Vrinda about this. Isha follows Devki and Bhola and finds out that the foreigner is the owner of the biggest adoption center in America. He wants two little cute girls so he can take them to America and someone could adopt them. Devki wants to sell Ira and Chutki to the foreigner. Isha is shocked and tells Arjun, Vrinda and Tinnu. When Devki is giving Ira and Chutki to the foreigner, Chetna comes. Devki kicks the foreigner out immediately. Every one were confused. They think that Chetna will buy one of the kids but Isha finds out that Chetna is the real owner of the place. She is really nice to all the children, gives them new clothes, good food, and new toys. On the day of Isha's birthday, Chetna organises a party for her. But Isha, Tinnu, Vrinda and all the kids plan to get Devki and Bhola kicked out from the orphanage. Isha calls some people to buy a child. Chetna sees this and Devki blames it on Bhola, who is then kicked out.

They all celebrate Isha's birthday and everyone is happy. Later one day, Isha goes to buy groceries with Calender. She sees a boy asking everyone about an orphanage and thinks he is a pickpocket. When he comes to her, they both drop their papers. Isha's paper had the groceries list and items, and his has the address to the orphanage. They accidentally pick up the wrong paper and he follows her there. He comes to the orphanage and everyone finds out his name: Samarth or Sam. He came from America and is Chetna's grandson. He tells everyone to hide him from Chetna for two days so Chetna doesn't send him back. Chetna gets a phone call from his mom saying he was supposed to go to summer camp but he's not there. Chetna is really worried and Devki thinks it's a good opportunity to send Chetna back but Isha tells her the truth. Sam is mad at Isha for telling Chetna the truth. Sam convinces Chetna to go to America with him and she agrees. Everyone is upset while Devki is happy. Meanwhile, Tinnu and Sam constantly fight a lot and argue. They both hate each other. Chetna borrows a baby from one of the guards and tells everyone on the street that until she is not adopted she won't go anywhere. The kids are all happy. Chetna tells Isha; she did it all this so Sam could become a responsible person. She assigns Isha, Tinnu and Sam to take care of the baby. Sam and Tinnu try to get along but they still fight. Sam is changing. Chetna is proud of Isha. Devki in a fit of greed for money teams up with Sam's mother to burn the orphanage. This causes all of the kids to be separated from each other, even Isha and Ira.

It came back on 3 January 2012 on Disney Channel India. It was picked up for 18 episodes, then 26, then 88.

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