Emilio Quaia

Emilio Quaia is an Italian radiologist, academic, and author. He is a professor of Radiology and the Director of the Radiology Department at the University of Padova.[1]

Emilio Quaia
Born
Italy
NationalityItalian
Occupation(s)Radiologist, academic and author
Academic background
EducationMD
M.S., Management and Direction of Health Organizations
M.S., Statistical Methods Applied to Clinical Questions
Academic work
InstitutionsUniversity of Padova

Quaia is the editor of the book Contrast Media in Ultrasonography: Basic Principles and Clinical Applications (Medical Radiology),[2] Radiological Imaging of the Kidney (Medical Radiology), and Imaging of the Liver and Intra-hepatic Biliary Tract (Medical Radiology). His research is focused in the field of Radiology, with a particular focus on contrast-enhanced ultrasound and liver, kidney and chest imaging.[3]

Quaia is a European Society of Urogenital Radiology and ESGAR fellow. He is the Editor-in-chief of a health journal, Tomography[4] and the Deputy Editor of Insights into Imaging.[5]

Education

Quaia got MD at University of Udine in 1995 and completed his Radiology residency at University of Trieste. He completed his Master's in Management and Direction of Health Organizations from the University of Trento in 2011. He then pursued another Master's in Statistical Methods Applied to Clinical Questions from the University of Modena and completed it in 2016.[1]

Career

Quaia started his academic career in 1999 as a research fellow at the Hammersmith Hospital London and worked there for a period of one year. He joined the Radiology department at the University of Trieste as an assistant professor in the same year and worked there up until 2014. He was then an associate professor of radiology at University of Trieste from 2014 to 2016. In 2016, he was appointed as a Senior Lecturer and an Honorary Consultant in Radiology at the University of Edinburgh. In 2018, he moved to University of Padova, becoming a professor.[1]

Quaia has been the Radiology Department's Chief at the University of Padova since 2018.[1]

Research

Quaia's research work focuses on Radiology with a particular focus on the fields of liver imaging, chest imaging, and contrast-enhanced ultrasound.[3]

Sonography

Quaia studied ultrasound imaging techniques, with a particular focus on contrast-enhanced ultrasound techniques (CEUS), and suggested employing CEUS techniques to clinically assess a patient suffering from Crohn's disease. He also advocated its use for surgical and therapeutical management of a patient suffering from Chron's disease due to its increased specificity and high sensitivity in tracking inflammatory activity.[6] He studied the impact of using contrast-enhanced ultrasound techniques in characterizing key liver lesions and demonstrated that post contrast agent administration, benign lesions depicted isoechoic effects in contrast to malignant lesions, which depicted hypoechoic effects, resulting in better characterization of focal liver lesions.[7] He also evaluated the effects of contrast-enhanced and unenhanced sonography in malignancy diagnosis of composite cystic renal masses and established the effectiveness of the former in detecting malignant activity in composite indeterminate cystic renal masses.[8]

Quaia also proposed the induction of micro-bubble-based agents to baseline ultrasound in an effort to enhance diagnostic capacity and suggested that the inclusion of microbubble-based agents can also help avoid MR examinations in various clinical situations.[9] Moreover, he examined tissue perfusion via contrast-enhanced ultrasound. He suggested employing reperfusion kinetics to efficiently acquire semiquantitative parameters pertaining to local tissue perfusion, specifically in the brain, heart, and kidneys, along with measuring organ transit time post microbubble injection administration.[10] He also investigated the characterization of renal parenchymal diseases, Ultrasound and Doppler Ultrasound for functional and morphological evaluation of renal parenchymal diseases citing their low sensitivity and specificity.[11]

Liver imaging

Quaia studied contrast enhancement patterns using a contrast agent, Levovist and demonstrated that Levovist could help diagnose liver hemangiomas since it showed a progressive fill-in on an ultrasound scan.[12] He also investigated the effects of radiotherapy on the biodistribution of Levovist on the liver and established that radiotherapy, at times, causes damage to the lining of blood vessels in the liver or Kupfer cells, which eventually affects the Levovist uptake.[13] He also studied the magnetic resonance diffusion-weighted technique and its role in evaluating chemotherapy's effectiveness for liver metastases. He emphasized that the pre-treatment ADC value of a lesion is not resourceful in predicting the effectiveness of chemotherapy; however, an early increase in the ADC value combined with a dimensional decrease of a lesion does indicate the effectiveness of chemotherapy in liver metastases.[14] He also examined the effects of contrast agents when administered in small amounts versus continuous infusion via a power injector. He demonstrated that the latter could help prolong the contrast enhancement period in the liver.[15]

In another research, Quaia investigated the ideal time delay to examine liver metastases on contrast-enhanced ultrasound and proposed a 40-60 secs delaying window post contrast agent administration for ideal visibility, both in terms of signal intensity and visual appearance.[16] He also explored the application of contrast-enhanced ultrasound in diagnosing pediatric liver problems, especially in the characterization of malignant and benign focal liver lesions. The study demonstrated that once the agent is injected into a vein, it stays in the blood vessels, streamlining the process of hepatic blood flow assessment.[17]

Bibliography

Books
  • Contrast Media in Ultrasonography: Basic Principles and Clinical Applications (2005) ISBN 9783540407409
  • Radiological Imaging of the Kidney (2011) ISBN 9783642540479
  • Imaging of the Liver and Intra-hepatic Biliary Tract (2021) ISBN 9783030389826

Selected articles
  • Quaia, E., & Bertolotto, M. (2002). Renal parenchymal diseases: is characterization feasible with ultrasound?. European radiology, 12(8), 2006–2020.
  • Quaia, E., Calliada, F., Bertolotto, M., Rossi, S., Garioni, L., Rosa, L., & Pozzi-Mucelli, R. (2004). Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride–filled microbubble contrast agent: diagnostic performance and confidence. Radiology, 232(2), 420–430.
  • Quaia, E., D’Onofrio, M., Palumbo, A., Rossi, S., Bruni, S., & Cova, M. (2006). Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence. European radiology, 16(7), 1599–1609.
  • Quaia, E. (2007). Microbubble ultrasound contrast agents: an update. European radiology, 17(8), 1995–2008.
  • Quaia, E., Bertolotto, M., Cioffi, V., Rossi, A., Baratella, E., Pizzolato, R., & Cova, M. A. (2008). Comparison of contrast-enhanced sonography with unenhanced sonography and contrast-enhanced CT in the diagnosis of malignancy in complex cystic renal masses. American Journal of Roentgenology, 191(4), 1239–1249.
  • Migaleddu, V., Scanu, A. M., Quaia, E., Rocca, P. C., Dore, M. P., Scanu, D., ... & Virgilio, G. (2009). Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease. Gastroenterology, 137(1), 43–52.

References
  1. "Emilio Quaia – University of Padova".
  2. Quaia, Emilio (8 March 2005). Contrast Media in Ultrasonography: Basic Principles and Clinical Applications. Springer Science & Business Media. ISBN 9783540407409 – via Google Books.
  3. "Emilio Quaia". scholar.google.it.
  4. "Tomography". www.mdpi.com.
  5. "About".
  6. Migaleddu, Vincenzo; Scanu, Antonio M.; Quaia, Emilio; Rocca, Paolo Cossu; Dore, Maria Pina; Scanu, Domenico; Azzali, Lorenza; Virgilio, Giuseppe (31 July 2009). "Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease". Gastroenterology. 137 (1): 43–52. doi:10.1053/j.gastro.2009.03.062. PMID 19422826 – via PubMed.
  7. Quaia, Emilio; Calliada, Fabrizio; Bertolotto, Michele; Rossi, Sandro; Garioni, Lorena; Rosa, Laura; Pozzi-Mucelli, Roberto (31 August 2004). "Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: diagnostic performance and confidence". Radiology. 232 (2): 420–430. doi:10.1148/radiol.2322031401. PMID 15286314 – via PubMed.
  8. Quaia, Emilio; Bertolotto, Michele; Cioffi, Vincenzo; Rossi, Alexia; Baratella, Elisa; Pizzolato, Riccardo; Cov, Maria Assunta (31 October 2008). "Comparison of contrast-enhanced sonography with unenhanced sonography and contrast-enhanced CT in the diagnosis of malignancy in complex cystic renal masses". AJR. American Journal of Roentgenology. 191 (4): 1239–1249. doi:10.2214/AJR.07.3546. PMID 18806171 – via PubMed.
  9. Quaia, Emilio, ed. (2005). Contrast Media in Ultrasonography. Medical Radiology. doi:10.1007/b138764. ISBN 3-540-40740-5 – via link.springer.com.
  10. Quaia, Emilio (1 March 2011). "Assessment of tissue perfusion by contrast-enhanced ultrasound". European Radiology. 21 (3): 604–615. doi:10.1007/s00330-010-1965-6. PMID 20927527. S2CID 21218637 – via Springer Link.
  11. Quaia, Emilio; Bertolotto, Michele (31 August 2002). "Renal parenchymal diseases: is characterization feasible with ultrasound?". European Radiology. 12 (8): 2006–2020. doi:10.1007/s00330-002-1360-z. PMID 12136319. S2CID 1578490 – via PubMed.
  12. Quaia, E.; Bartolotta, T. V.; Midiri, M.; Cernic, S.; Belgrano, M.; Cova, M. (31 January 2006). "Analysis of different contrast enhancement patterns after microbubble-based contrast agent injection in liver hemangiomas with atypical appearance on baseline scan". Abdominal Imaging. 31 (1): 59–64. doi:10.1007/s00261-005-0358-9. PMID 16333704. S2CID 10853672 – via PubMed.
  13. Quaia, Emilio; Blomley, Martin J. K; Patel, Shetal; Harvey, Christopher J; Padhani, Anwar; Price, Pat; Cosgrove, David O (1 March 2002). "Initial observations on the effect of irradiation on the liver-specific uptake of Levovist". European Journal of Radiology. 41 (3): 192–199. doi:10.1016/S0720-048X(01)00458-2. PMID 11861093 – via ScienceDirect.
  14. Mungai, Francesco; Pasquinelli, Filippo; Mazzoni, Lorenzo Nicola; Virgili, Gianni; Ragozzino, Alfonso; Quaia, Emilio; Morana, Giovanni; Giovagnoni, Andrea; Grazioli, Luigi; Colagrande, Stefano (31 August 2014). "Diffusion-weighted magnetic resonance imaging in the prediction and assessment of chemotherapy outcome in liver metastases". La Radiologia Medica. 119 (8): 625–633. doi:10.1007/s11547-013-0379-3. PMID 24408046. S2CID 12829213 – via PubMed.
  15. Quaia, Emilio; Gennari, Antonio Giulio; Angileri, Roberta; Cova, Maria Assunta (31 January 2016). "Bolus versus continuous infusion of microbubble contrast agent for liver ultrasound by using an automatic power injector in humans: A pilot study". Journal of Clinical Ultrasound. 44 (3): 136–142. doi:10.1002/jcu.22293. hdl:11368/2867307. PMID 26302446. S2CID 5700126 – via PubMed.
  16. Quaia, E.; Gennari, A. G. (2018). "The Most Appropriate Time Delay after Microbubble Contrast Agent Intravenous Injection to Maximize Liver Metastasis Conspicuity on Contrast-Enhanced Ultrasound". Journal of Medical Ultrasound. 26 (3): 128–133. doi:10.4103/JMU.JMU_12_17. PMC 6159328. PMID 30283198.
  17. Fang, C.; Anupindi, S. A.; Back, S. J.; Franke, D.; Green, T. G.; Harkanyi, Z.; Jüngert, J.; Kwon, J. K.; Paltiel, H. J.; Squires, J. H.; Zefov, V. N.; McCarville, M. B. (2021). "Contrast-enhanced ultrasound of benign and malignant liver lesions in children". Pediatric Radiology. 51 (12): 2181–2197. doi:10.1007/s00247-021-04976-2. PMC 8566652. PMID 33978801.
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