Endothelin converting enzyme 1

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.[5][6][7]

ECE1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesECE1, ECE, endothelin converting enzyme 1
External IDsOMIM: 600423 MGI: 1101357 HomoloGene: 1068 GeneCards: ECE1
Orthologs
SpeciesHumanMouse
Entrez

1889

230857

Ensembl

ENSG00000117298

ENSMUSG00000057530

UniProt

P42892

Q4PZA2

RefSeq (mRNA)

NM_001113347
NM_001113348
NM_001113349
NM_001397

NM_199307
NM_001369177
NM_001369178
NM_001369179

RefSeq (protein)

NP_001106818
NP_001106819
NP_001106820
NP_001388
NP_001106820.1

NP_955011
NP_001356106
NP_001356107
NP_001356108

Location (UCSC)Chr 1: 21.22 – 21.35 MbChr 4: 137.59 – 137.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000117298 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000057530 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ECE1 endothelin converting enzyme 1".
  6. Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H (December 1994). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. doi:10.1016/0014-5793(94)01277-6. PMID 7805846.
  7. Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K (February 1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. doi:10.1006/bbrc.1995.1258. PMID 7864876.

Further reading


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