Ensconsin

Ensconsin is a protein that in humans is encoded by the MAP7 gene.[5][6]

MAP7
Identifiers
AliasesMAP7, E-MAP-115, EMAP115, microtubule associated protein 7
External IDsOMIM: 604108 MGI: 1328328 HomoloGene: 20851 GeneCards: MAP7
Orthologs
SpeciesHumanMouse
Entrez

9053

17761

Ensembl

ENSG00000135525

ENSMUSG00000019996

UniProt

Q14244

O88735

RefSeq (mRNA)

NM_001198635
NM_001198636
NM_008635
NM_001358787

RefSeq (protein)

NP_001185564
NP_032661
NP_001345716

Location (UCSC)Chr 6: 136.34 – 136.55 MbChr 10: 20.02 – 20.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.[6]

In addition, MAPs also play a role in regulating cellular transport. MAP7 is a necessary cofactor to activate and subsequently transport cargos by Kinesin-1. [7] [8]

MAP7's effect on Dynein is still debated.[9] [10]

Interactions

MAP7 has been shown to interact with TRPV4.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000135525 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019996 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Masson D, Kreis TE (October 1993). "Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells". The Journal of Cell Biology. 123 (2): 357–371. doi:10.1083/jcb.123.2.357. PMC 2119845. PMID 8408219.
  6. "Entrez Gene: MAP7 microtubule-associated protein 7".
  7. Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes GJ, Peeters CA, Katrukha EA, et al. (April 2019). "MAP7 family proteins regulate kinesin-1 recruitment and activation". The Journal of Cell Biology. 218 (4): 1298–1318. doi:10.1083/jcb.201808065. PMC 6446838. PMID 30770434.
  8. Monroy BY, Tan TC, Oclaman JM, Han JS, Simó S, Niwa S, et al. (April 2020). "A Combinatorial MAP Code Dictates Polarized Microtubule Transport". Developmental Cell. 53 (1): 60–72.e4. doi:10.1016/j.devcel.2020.01.029. PMC 7181406. PMID 32109385.
  9. Monroy BY, Sawyer DL, Ackermann BE, Borden MM, Tan TC, Ori-McKenney KM (April 2018). "Competition between microtubule-associated proteins directs motor transport". Nature Communications. 9 (1): 1487. doi:10.1038/s41467-018-03909-2. PMC 5902456. PMID 29662074.
  10. Ferro LS, Fang Q, Eshun-Wilson L, Fernandes J, Jack A, Farrell DP, et al. (January 2022). "Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7". Science. 375 (6578): 326–331. doi:10.1126/science.abf6154. PMID 35050657.
  11. Suzuki M, Hirao A, Mizuno A (December 2003). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)". The Journal of Biological Chemistry. 278 (51): 51448–51453. doi:10.1074/jbc.M308212200. PMID 14517216.

Further reading

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