Environment-wide association study

An environment-wide association study, also known as an environmental-wide association study (abbreviated EWAS), is a type of epidemiological study analogous to the genome-wide association study, or GWAS. The EWAS systematically examines the association between a complex disease and multiple individual environmental factors, controlling for multiple hypothesis testing.[1][2][3]

References

Patel, Chirag J.; Bhattacharya, Jayanta; Butte, Atul J. (2010-05-20). Zhang, Baohong (ed.). "An Environment-Wide Association Study (EWAS) on Type 2 Diabetes Mellitus". PLOS ONE. 5 (5): e10746. Bibcode:2010PLoSO...510746P. doi:10.1371/journal.pone.0010746. ISSN 1932-6203. PMC 2873978. PMID 20505766.
Zhuang, Xiaodong; Ni, Ao; Liao, Lizhen; Guo, Yue; Dai, Wei; Jiang, Yunxi; Zhou, Huimin; Hu, Xun; Du, Zhimin; Wang, Xueqin; Liao, Xinxue (February 2018). "Environment-wide association study to identify novel factors associated with peripheral arterial disease: Evidence from the National Health and Nutrition Examination Survey (1999–2004)". Atherosclerosis. 269: 172–177. doi:10.1016/j.atherosclerosis.2018.01.006. PMID 29366990. S2CID 46876807.
McGinnis, Denise P.; Brownstein, John S.; Patel, Chirag J. (September 2016). "Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999–2012)". Scientific Reports. 6 (1): 30373. Bibcode:2016NatSR...630373M. doi:10.1038/srep30373. ISSN 2045-2322. PMC 4960597. PMID 27457472.

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[1] Patel, Chirag J.; Bhattacharya, Jayanta; Butte, Atul J. (2010-05-20). Zhang, Baohong (ed.). "An Environment-Wide Association Study (EWAS) on Type 2 Diabetes Mellitus". PLOS ONE. 5 (5): e10746. Bibcode:2010PLoSO...510746P. doi:10.1371/journal.pone.0010746. ISSN 1932-6203. PMC 2873978. PMID 20505766.

[2] Zhuang, Xiaodong; Ni, Ao; Liao, Lizhen; Guo, Yue; Dai, Wei; Jiang, Yunxi; Zhou, Huimin; Hu, Xun; Du, Zhimin; Wang, Xueqin; Liao, Xinxue (February 2018). "Environment-wide association study to identify novel factors associated with peripheral arterial disease: Evidence from the National Health and Nutrition Examination Survey (1999–2004)". Atherosclerosis. 269: 172–177. doi:10.1016/j.atherosclerosis.2018.01.006. PMID 29366990. S2CID 46876807.

[3] McGinnis, Denise P.; Brownstein, John S.; Patel, Chirag J. (September 2016). "Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999–2012)". Scientific Reports. 6 (1): 30373. Bibcode:2016NatSR...630373M. doi:10.1038/srep30373. ISSN 2045-2322. PMC 4960597. PMID 27457472.